FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896866335> ?p ?o ?g. }

• W2896866335 abstract "Antigen recognition by the T cell receptor (TCR) directs the assembly of essential signaling complexes known as SLP-76 microclusters. Here, we show that the interaction of the adhesion and degranulation-promoting adaptor protein (ADAP) with SLP-76 enables the formation of persistent microclusters and the stabilization of T cell contacts, promotes integrin-independent adhesion, and enables the upregulation of CD69. Using point mutants and a novel phospho-specific antibody, we show that Y595 is essential for normal ADAP function, that virtually all tyrosine phosphorylation of ADAP is restricted to a Y595-phosphorylated pool, and that multivalent interactions between the SLP-76 SH2 domain and its binding sites in ADAP are required to sustain ADAP phosphorylation. Although pY595 ADAP enters SLP-76 microclusters, un-phosphorylated ADAP is enriched in protrusive actin-rich structures. The pre-positioning of ADAP at the contact sites generated by these structures favors the retention of nascent SLP-76 oligomers and their assembly into persistent microclusters. Although ADAP is frequently depicted as an effector of SLP-76, our findings reveal that ADAP acts upstream of SLP-76 to convert labile, calcium-competent microclusters into stable adhesive junctions with enhanced signaling potential." @default.
• W2896866335 created "2018-10-26" @default.
• W2896866335 creator A5000580336 @default.
• W2896866335 creator A5003394849 @default.
• W2896866335 creator A5014581773 @default.
• W2896866335 creator A5017951070 @default.
• W2896866335 creator A5024844829 @default.
• W2896866335 creator A5029155584 @default.
• W2896866335 creator A5034426895 @default.
• W2896866335 creator A5053684742 @default.
• W2896866335 creator A5060878313 @default.
• W2896866335 date "2018-01-01" @default.
• W2896866335 modified "2023-09-26" @default.
• W2896866335 title "ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters" @default.
• W2896866335 cites W1540070193 @default.
• W2896866335 cites W1588634397 @default.
• W2896866335 cites W1631329616 @default.
• W2896866335 cites W1657823335 @default.
• W2896866335 cites W1836460175 @default.
• W2896866335 cites W1882749752 @default.
• W2896866335 cites W1957196088 @default.
• W2896866335 cites W1974374103 @default.
• W2896866335 cites W1978359047 @default.
• W2896866335 cites W1980482849 @default.
• W2896866335 cites W1981565131 @default.
• W2896866335 cites W1982905247 @default.
• W2896866335 cites W1983635410 @default.
• W2896866335 cites W1984567041 @default.
• W2896866335 cites W1985272248 @default.
• W2896866335 cites W1985849661 @default.
• W2896866335 cites W1987904129 @default.
• W2896866335 cites W1988783201 @default.
• W2896866335 cites W1990092210 @default.
• W2896866335 cites W1990634604 @default.
• W2896866335 cites W1994246321 @default.
• W2896866335 cites W2003397171 @default.
• W2896866335 cites W2010281141 @default.
• W2896866335 cites W2013014779 @default.
• W2896866335 cites W2013862100 @default.
• W2896866335 cites W2014575820 @default.
• W2896866335 cites W2017068352 @default.
• W2896866335 cites W2022275019 @default.
• W2896866335 cites W2023276714 @default.
• W2896866335 cites W2024267421 @default.
• W2896866335 cites W2025072577 @default.
• W2896866335 cites W2032335449 @default.
• W2896866335 cites W2035136679 @default.
• W2896866335 cites W2035732298 @default.
• W2896866335 cites W2040098705 @default.
• W2896866335 cites W2040569532 @default.
• W2896866335 cites W2045358326 @default.
• W2896866335 cites W2047222096 @default.
• W2896866335 cites W2051303299 @default.
• W2896866335 cites W2055864348 @default.
• W2896866335 cites W2061506791 @default.
• W2896866335 cites W2071442472 @default.
• W2896866335 cites W2071745846 @default.
• W2896866335 cites W2071751102 @default.
• W2896866335 cites W2076725876 @default.
• W2896866335 cites W2080318948 @default.
• W2896866335 cites W2083375615 @default.
• W2896866335 cites W2087109991 @default.
• W2896866335 cites W2094338475 @default.
• W2896866335 cites W2096563079 @default.
• W2896866335 cites W2098325534 @default.
• W2896866335 cites W2098409714 @default.
• W2896866335 cites W2098489923 @default.
• W2896866335 cites W2099496436 @default.
• W2896866335 cites W2099540110 @default.
• W2896866335 cites W2102536703 @default.
• W2896866335 cites W2102758445 @default.
• W2896866335 cites W2103845807 @default.
• W2896866335 cites W2113520409 @default.
• W2896866335 cites W2116922620 @default.
• W2896866335 cites W2121036696 @default.
• W2896866335 cites W2129997470 @default.
• W2896866335 cites W2131673648 @default.
• W2896866335 cites W2132279425 @default.
• W2896866335 cites W2135630804 @default.
• W2896866335 cites W2138197182 @default.
• W2896866335 cites W2138421443 @default.
• W2896866335 cites W2141126754 @default.
• W2896866335 cites W2144147853 @default.
• W2896866335 cites W2152548397 @default.
• W2896866335 cites W2153724323 @default.
• W2896866335 cites W2154907254 @default.
• W2896866335 cites W2154969164 @default.
• W2896866335 cites W2156517168 @default.
• W2896866335 cites W2158447472 @default.
• W2896866335 cites W2160332408 @default.
• W2896866335 cites W2163186181 @default.
• W2896866335 cites W2163295981 @default.
• W2896866335 cites W2167127449 @default.
• W2896866335 cites W2169936410 @default.
• W2896866335 cites W2467427117 @default.
• W2896866335 cites W2474130090 @default.
• W2896866335 cites W2613004608 @default.
• W2896866335 doi "https://doi.org/10.1242/jcs.215517" @default.
• W2896866335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6240300" @default.
• W2896866335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305305" @default.

• next