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• W2896868453 abstract "Tissue plasminogen activator (tPA) thrombolysis continues to be the gold standard therapy for ischemic stroke. Due to the time-limited treatment window, within 4.5 h of stroke onset, and a variety of potentially deadly complications related to delayed administration, particularly hemorrhagic transformation (HT), clinical use of tPA is limited. Combination therapies with other interventions, drug or nondrug, have been hypothesized as a logical approach to enhancing tPA effectiveness. Here, we discuss various potential pharmacological and nondrug treatments to minimize adverse effects, primarily HT, associated with delayed tPA administration. Pharmacological interventions include many that support the integrity of the blood–brain barrier (i.e., atorvastatin, batimastat, candesartan, cilostazol, fasudil, and minocycline), promote vascularization and preserve cerebrovasculature (i.e., coumarin derivative IMM-H004 and granulocyte-colony stimulating factor), employing other mechanisms of action (i.e., oxygen transporters and ascorbic acid). Nondrug treatments are comprised of stem cell transplantation and gas therapies with multi-faceted approaches. Combination therapy with tPA and the aforementioned treatments demonstrated promise for mitigating the adverse complications associated with delayed tPA treatment and rescuing stroke-induced behavioral deficits. Therefore, the conjunctive therapy method is a novel therapeutic approach that can attempt to minimize the limitations of tPA treatment and possibly increase the therapeutic window for ischemic stroke treatment." @default.
• W2896868453 created "2018-10-26" @default.
• W2896868453 creator A5031819589 @default.
• W2896868453 creator A5035194870 @default.
• W2896868453 creator A5040059449 @default.
• W2896868453 date "2018-01-01" @default.
• W2896868453 modified "2023-10-18" @default.
• W2896868453 title "Combination therapy for ischemic stroke: Novel approaches to lengthen therapeutic window of tissue plasminogen activator" @default.
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• W2896868453 doi "https://doi.org/10.4103/bc.bc_21_18" @default.
• W2896868453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187940" @default.
• W2896868453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30450415" @default.
• W2896868453 hasPublicationYear "2018" @default.
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