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• W2896870868 abstract "To better understand how quantitative sensory testing could help the clinician in the management of oxaliplatin-induced peripheral neuropathy in terms of earlier and more reliable detection, we conducted a two-year prospective study.Thermal sensory assessment, tactile sensory assessment, neuropathic pain assessment and adverse events gradation (NCI-CTC) were performed during treatment and 6 months after treatment completion.35 patients were enrolled and followed-up during one year. Cold and Warm Detection Thresholds were higher 6 months after treatment completion than at enrollment. Mechanical detection thresholds didn't change significantly. Neurotoxicity was mostly grade-1, only 18% grade-2 and no grade-3. Grade-2 patients received lower oxaliplatin cumulative dose than grade-1, which reveals effective dose adaptation and grade-2 patients were more likely to develop painful neuropathy.Thermal thresholds impairment emerges too late to help the clinician in the prophylaxis of neuropathy. Management of OXA-treatment based on NCI-CTC, as currently recommended, remains the best way to detect neuropathy and ensure treatment adaptation." @default.
• W2896870868 created "2018-10-26" @default.
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• W2896870868 date "2018-01-01" @default.
• W2896870868 modified "2023-10-13" @default.
• W2896870868 title "Is quantitative sensory testing helpful in the management of oxaliplatin neuropathy? a two-year clinical study" @default.
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• W2896870868 doi "https://doi.org/10.1016/j.ctarc.2018.10.002" @default.
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