FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896874217> ?p ?o ?g. }

• W2896874217 endingPage "420" @default.
• W2896874217 startingPage "414" @default.
• W2896874217 abstract "There is a paucity of data on the effect of early de-escalation of antimicrobial therapy on rates of Clostridioides difficile infection (CDI). This retrospective cohort study evaluated impact of de-escalation from antipseudomonal β-lactam (APBL) therapy within 48 hours of Enterobacteriaceae bloodstream infections (BSIs) on 90-day risk of CDI.Adult patients hospitalized for >48 hours for treatment of Enterobacteriaceae BSI at Palmetto Health hospitals in Columbia, South Carolina, from 1 January 2011 through 30 June 2015 were identified. Multivariable Cox proportional hazards regression was used to examine time to CDI in patients who received >48 hours or ≤48 hours of APBL for empirical therapy of Enterobacteriaceae BSI after adjustment for the propensity to receive >48 hours of APBL.Among 808 patients with Enterobacteriaceae BSI, 414 and 394 received >48 and ≤48 hours of APBL, respectively. Incidence of CDI was higher in patients who received >48 hours than those who received ≤48 hours of APBL (7.0% vs 1.8%; log-rank P = .002). After adjustment for propensity to receive >48 hours of APBL and other variables in the multivariable model, receipt of >48 hours of APBL (hazard ratio [HR], 3.56 [95% confidence interval {CI}, 1.48-9.92]; P = .004) and end-stage renal disease (HR, 4.27 [95% CI, 1.89-9.11]; P = .001) were independently associated with higher risk of CDI.The empirical use of APBL for >48 hours was an independent risk factor for CDI. Early de-escalation of APBL using clinical risk assessment tools or rapid diagnostic testing may reduce the incidence of CDI in hospitalized adults with Enterobacteriaceae BSIs." @default.
• W2896874217 created "2018-10-26" @default.
• W2896874217 creator A5002750559 @default.
• W2896874217 creator A5009190500 @default.
• W2896874217 creator A5015829437 @default.
• W2896874217 creator A5030186453 @default.
• W2896874217 creator A5038348654 @default.
• W2896874217 creator A5042758151 @default.
• W2896874217 creator A5046584029 @default.
• W2896874217 creator A5070087986 @default.
• W2896874217 creator A5072489756 @default.
• W2896874217 date "2018-10-12" @default.
• W2896874217 modified "2023-09-26" @default.
• W2896874217 title "Role of Early De-escalation of Antimicrobial Therapy on Risk of Clostridioides difficile Infection Following Enterobacteriaceae Bloodstream Infections" @default.
• W2896874217 cites W1931530377 @default.
• W2896874217 cites W1954938267 @default.
• W2896874217 cites W1966533567 @default.
• W2896874217 cites W1974883267 @default.
• W2896874217 cites W1982057684 @default.
• W2896874217 cites W2000445173 @default.
• W2896874217 cites W2001280008 @default.
• W2896874217 cites W2007686871 @default.
• W2896874217 cites W2091911714 @default.
• W2896874217 cites W2100217657 @default.
• W2896874217 cites W2112459888 @default.
• W2896874217 cites W2115717127 @default.
• W2896874217 cites W2120380373 @default.
• W2896874217 cites W2134091331 @default.
• W2896874217 cites W2138325813 @default.
• W2896874217 cites W2147661229 @default.
• W2896874217 cites W2159643438 @default.
• W2896874217 cites W2210158789 @default.
• W2896874217 cites W2496527871 @default.
• W2896874217 cites W2508190125 @default.
• W2896874217 cites W2523533059 @default.
• W2896874217 cites W2523557015 @default.
• W2896874217 cites W2525392288 @default.
• W2896874217 cites W2564122201 @default.
• W2896874217 cites W2609966493 @default.
• W2896874217 cites W2621471882 @default.
• W2896874217 cites W2712826668 @default.
• W2896874217 cites W2767359853 @default.
• W2896874217 cites W2784074338 @default.
• W2896874217 cites W2791368209 @default.
• W2896874217 doi "https://doi.org/10.1093/cid/ciy863" @default.
• W2896874217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30312362" @default.
• W2896874217 hasPublicationYear "2018" @default.
• W2896874217 type Work @default.
• W2896874217 sameAs 2896874217 @default.
• W2896874217 citedByCount "34" @default.
• W2896874217 countsByYear W28968742172018 @default.
• W2896874217 countsByYear W28968742172019 @default.
• W2896874217 countsByYear W28968742172020 @default.
• W2896874217 countsByYear W28968742172021 @default.
• W2896874217 countsByYear W28968742172022 @default.
• W2896874217 countsByYear W28968742172023 @default.
• W2896874217 crossrefType "journal-article" @default.
• W2896874217 hasAuthorship W2896874217A5002750559 @default.
• W2896874217 hasAuthorship W2896874217A5009190500 @default.
• W2896874217 hasAuthorship W2896874217A5015829437 @default.
• W2896874217 hasAuthorship W2896874217A5030186453 @default.
• W2896874217 hasAuthorship W2896874217A5038348654 @default.
• W2896874217 hasAuthorship W2896874217A5042758151 @default.
• W2896874217 hasAuthorship W2896874217A5046584029 @default.
• W2896874217 hasAuthorship W2896874217A5070087986 @default.
• W2896874217 hasAuthorship W2896874217A5072489756 @default.
• W2896874217 hasConcept C120665830 @default.
• W2896874217 hasConcept C121332964 @default.
• W2896874217 hasConcept C126322002 @default.
• W2896874217 hasConcept C167135981 @default.
• W2896874217 hasConcept C201903717 @default.
• W2896874217 hasConcept C207103383 @default.
• W2896874217 hasConcept C2779443120 @default.
• W2896874217 hasConcept C2910067853 @default.
• W2896874217 hasConcept C44249647 @default.
• W2896874217 hasConcept C501593827 @default.
• W2896874217 hasConcept C50382708 @default.
• W2896874217 hasConcept C61511704 @default.
• W2896874217 hasConcept C71924100 @default.
• W2896874217 hasConcept C86803240 @default.
• W2896874217 hasConcept C89423630 @default.
• W2896874217 hasConceptScore W2896874217C120665830 @default.
• W2896874217 hasConceptScore W2896874217C121332964 @default.
• W2896874217 hasConceptScore W2896874217C126322002 @default.
• W2896874217 hasConceptScore W2896874217C167135981 @default.
• W2896874217 hasConceptScore W2896874217C201903717 @default.
• W2896874217 hasConceptScore W2896874217C207103383 @default.
• W2896874217 hasConceptScore W2896874217C2779443120 @default.
• W2896874217 hasConceptScore W2896874217C2910067853 @default.
• W2896874217 hasConceptScore W2896874217C44249647 @default.
• W2896874217 hasConceptScore W2896874217C501593827 @default.
• W2896874217 hasConceptScore W2896874217C50382708 @default.
• W2896874217 hasConceptScore W2896874217C61511704 @default.
• W2896874217 hasConceptScore W2896874217C71924100 @default.
• W2896874217 hasConceptScore W2896874217C86803240 @default.
• W2896874217 hasConceptScore W2896874217C89423630 @default.
• W2896874217 hasIssue "3" @default.
• W2896874217 hasLocation W28968742171 @default.

• next