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- W2896874637 endingPage "97" @default.
- W2896874637 startingPage "72" @default.
- W2896874637 abstract "Fatal unintentional poisoning is widespread upon human exposure to toxic agents such as pesticides, heavy metals, environmental pollutants, bacterial and fungal toxins or even some medications and cosmetic products. In this regards, the application of the natural dietary agents as antidotes has engrossed a substantial attention. One of the ancient known traditional medicines and spices with an arsenal of metabolites of several reported health benefits is ginger. This extended literature review serves to demonstrate the protective effects and mechanisms of ginger and its phytochemicals against natural, chemical and radiation-induced toxicities. Collected data obtained from the in-vivo and in-vitro experimental studies in this overview detail the designation of the protective effects to ginger's antioxidant, anti-inflammatory, and anti-apoptotic properties. Ginger's armoury of phytochemicals exerted its protective function via different mechanisms and cell signalling pathways, including Nrf2/ARE, MAPK, NF-ƙB, Wnt/β-catenin, TGF-β1/Smad3, and ERK/CREB. The outcomes of this review could encourage further clinical trials of ginger applications in radiotherapy and chemotherapy regime for cancer treatments or its implementation to counteract the chemical toxicity induced by industrial pollutants, alcohol, smoking or administered drugs." @default.
- W2896874637 created "2018-10-26" @default.
- W2896874637 creator A5000957024 @default.
- W2896874637 creator A5037700528 @default.
- W2896874637 creator A5049605034 @default.
- W2896874637 creator A5051651663 @default.
- W2896874637 creator A5055621456 @default.
- W2896874637 creator A5071553375 @default.
- W2896874637 creator A5084461358 @default.
- W2896874637 creator A5088148593 @default.
- W2896874637 date "2019-01-01" @default.
- W2896874637 modified "2023-09-25" @default.
- W2896874637 title "Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review" @default.
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