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• W2896874687 abstract "To examine the relationship between diabetic propensity indexed by fasting blood glucose in males and females with patterns of metabolic decline within areas of the brain specifically involved in verbal memory and/or language function. 160 FDG-PET scans from 50 longitudinally studied Alzheimer's Disease Neuroimaging subjects were analyzed. Scans from equal numbers of men and women acquired at annual intervals from baseline to 2-3 years were regionally quantified by standardized volume of interest methods, normalized to whole-brain activity. Rates of metabolic change were assessed for left cerebral hemisphere, in anteromedial temporal (MAT) and Broca's areas. Significance of differences between subject groups was assessed by chi-square and two-tailed t tests. Men and women did not significantly differ at baseline with respect to overall cognition (MMSE = 28.0±1.3, 28.1±1.9, respectively; mean±SD), fasting blood glucose level (98.9±16.2, 101.7±18.6), or APOE4 status (64% of males and 72% of females APOE4-negative), and were similarly represented in having fasting glucose levels above 100 (109.8 ±15.1; 11 males, 9 females), or in normoglycemic range (85.9±7.2; 14 males, 16 females). At baseline, women with MCI had significantly higher metabolism than men (p<0.05) in both Broca's (1.20±0.01, 1.17±0.01; mean±SEM) and MAT (0.745±0.004, 0.730±0.004) areas. Women with MCI, but not men, experienced metabolic decline in both areas during the 2-3 years follow-up, and also demonstrated a positive correlation between annual rates of metabolic decline in each area with higher fasting blood glucose levels. Female sex is a risk factor for development of dementia for reasons that are incompletely understood. Verbal memory performance is higher in women than men, as is metabolism within the frontal and medial temporal regions involved in mediating it. Both medial temporal and Broca's areas tended to metabolically decline faster in women with MCI than in men, and that decline in women (but not men) was accelerated by higher fasting blood glucose levels. The observed changes in regional cerebral metabolism may thus point to exacerbating interactions between known risk factors for Alzheimer's disease development, and the possibility that maintaining normoglycemic status may be of particular benefit among women with elevated risk for developing dementia." @default.
• W2896874687 created "2018-10-26" @default.
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• W2896874687 date "2018-07-01" @default.
• W2896874687 modified "2023-10-16" @default.
• W2896874687 title "P3‐444: ASSESSING IMPACT OF DIABETIC PROPENSITY AND SEX IN SUBJECTS WITH NORMAL OR IMPAIRED COGNITION ON TRAJECTORIES OF METABOLIC DECLINE IN BROCA'S AREA AND TEMPORAL CORTEX" @default.
• W2896874687 doi "https://doi.org/10.1016/j.jalz.2018.06.1807" @default.
• W2896874687 hasPublicationYear "2018" @default.
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