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• W2896874934 abstract "The aim of the present study is to encapsulate antitubercular drugs Rifampicin (RIF) and Isoniazid (INH) in core-shell micelles of ethylene oxide-propylene oxide (EO-PO) triblock copolymers, Pluronics® (P84, P85, P103, P105, P123 and F127). The formulations were characterized using FTIR, which showed no chemical or physical interaction of drugs with polymers. In vitro release profiles of drugs using different kinetic models suggested diffusion controlled release. When evaluated against MDR strain of Mycobacterium tuberculosis, micelles showed improved antibacterial activity of drugs relative to corresponding free drug solutions. We further investigated the effects of block copolymers on the intestinal absorption of RIF and INH. Compared to free drugs, micelles showed improved drug permeability across Caco-2 monolayer. Our results suggest that polymer micelles are promising vehicles for delivering antitubercular drugs RIF and INH in a more effective manner." @default.
• W2896874934 created "2018-10-26" @default.
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• W2896874934 date "2018-12-01" @default.
• W2896874934 modified "2023-10-14" @default.
• W2896874934 title "Preparation and characterization of anti-tubercular drugs encapsulated in polymer micelles" @default.
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• W2896874934 doi "https://doi.org/10.1016/j.jddst.2018.10.021" @default.
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