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• W2896875806 abstract "The clinical course in patients with prostate cancer (PCa) after biochemical failure (BF) has received limited attention. We analyze survival time from recurrence, patterns of progression, and the efficacy of salvage therapies in patients treated with radical or postoperative radiotherapy (RT). Multicenter retrospective comparative study of 1135 patients diagnosed with BF and treated with either radical (882) or postoperative (253) RT. Data were acquired from the RECAP (Spanish Registry of Prostate Cancer) database. Clinical, tumor, and therapeutic characteristics were collected. Descriptive statistics, survival estimates, and comparisons of survival rates were performed. Time to BF from initial treatment (RT or surgery) was higher in irradiated patients (51 vs 37 months). At a median follow-up of 102 months [14-254], the 8-year cause-specific survival (CSS) was 80.5%, without significant differences between the radical (80.1%) and postoperative (83.4%) RT groups. The 8-year metastasis-free survival rate was 57%. 173 patients (15%) died of PCa and 29 (2.5%) of a second cancer. No salvage therapy was given in 15% of pts. Only 5.5% of pts who underwent radical RT had local salvage treatment and 71% received androgen deprivation (AD) ± chemotherapy. The worst outcomes were in patients who developed metastases after BF (302 pts; 26.5%) and in cases with a Gleason >7. In PCa treated with radiotherapy, median survival after BF is relatively long. In this sample, we found no differences in survival rates at 8-years, regardless of the time of radiotherapy administered. AD was the most common treatment after BF. Metastases and high Gleason score are adverse variables." @default.
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• W2896875806 date "2018-11-01" @default.
• W2896875806 modified "2023-10-01" @default.
• W2896875806 title "Survival after Biochemical Failure in Prostate Cancer Treated with Radiation Therapy" @default.
• W2896875806 doi "https://doi.org/10.1016/j.ijrobp.2018.07.309" @default.
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