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• W2896879364 abstract "Myeloid-derived suppressor cells (MDSCs) promote tumor-mediated immunosuppression and cancer progression. Gemcitabine (Gem) is a MDSC-depleting chemotherapeutic agent; however, its clinical use is hampered by its drug resistance and inefficient in vivo delivery. Here we describe a strategy to formulate a Gem analogue gemcitabine monophosphate (GMP) into a lipid-coated calcium phosphate (LCP) nanoparticle, and investigate its antitumor immunity and therapeutic effects after systemic administrations. In the syngeneic mouse model of B16F10 melanoma, compared with free Gem, the LCP-formulated GMP (LCP-GMP) significantly induced apoptosis and reduced immunosuppression in the tumor microenvironment (TME). LCP-GMP effectively depleted MDSCs and regulatory T cells, and skewed macrophage polarization towards the antitumor M1 phenotype in the TME, leading to enhanced CD8+ T-cell immune response and profound tumor growth inhibition. Thus, engineering the in vivo delivery of MDSC-depleting agents using nanotechnology could substantially modulate immunosuppressive TME and boost T-cell immune response for enhanced antitumor efficacy." @default.
• W2896879364 created "2018-10-26" @default.
• W2896879364 creator A5018764359 @default.
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• W2896879364 date "2019-01-01" @default.
• W2896879364 modified "2023-09-23" @default.
• W2896879364 title "Gemcitabine nanoparticles promote antitumor immunity against melanoma" @default.
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• W2896879364 doi "https://doi.org/10.1016/j.biomaterials.2018.10.022" @default.
• W2896879364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6281175" @default.
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• W2896879364 hasPublicationYear "2019" @default.
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