Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896880451> ?p ?o ?g. }
- W2896880451 endingPage "3226" @default.
- W2896880451 startingPage "3226" @default.
- W2896880451 abstract "Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic drugs, implicated in pleiotropic secondary cardioprotective effects. The aim of the study was to unveil the unknown and possible cardioprotective targets that can be exerted by sitagliptin (Sitg) against ischemia-reperfusion (I/R) injury. Male wistar rats received 2 weeks’ Sitg oral treatment of different doses (25, 50, 100, and 150 mg/kg/day), or saline as a Control. Hearts were then isolated and subjected to two different I/R injury protocols: 10 min perfusion, 45 min regional ischemia, and 120 min reperfusion for infarct size (IS) measurement, or: 10 min perfusion, 45 min regional ischemia and 10 min reperfusion for biochemical analysis: nitric oxide synthases (NOSs) and DPP-4 activity, glucagon-like peptide-1 (GLP-1), Calcium, transient receptor potential vanilloid (TRPV)-1 and calcitonin gene-related peptide (CGRP) levels, transient receptor potential canonical (TRPC)-1 and e-NOS protein expression. NOS inhibitor (l-NAME) and TRPV-1 inhibitor (Capsazepine) were utilized to confirm the implication of both signaling mechanisms in DPP-4 inhibition-induced at the level of IS. Findings show that Sitg (50 mg) resulted in significant decrease in IS and DPP-4 activity, and significant increase in GLP-1, NOS activity, e-NOS expression, TRPV-1 level and TRPC-1 expression, compared to controls. Results of CGRP are in line with TRPV-1, as a downstream regulatory effect. NOS system and transient receptor potential (TRP) channels can contribute to DPP-4 inhibition-mediated cardioprotection against I/R injury using Sitagliptin." @default.
- W2896880451 created "2018-10-26" @default.
- W2896880451 creator A5016594705 @default.
- W2896880451 creator A5023626251 @default.
- W2896880451 creator A5027702960 @default.
- W2896880451 creator A5039024324 @default.
- W2896880451 creator A5050756842 @default.
- W2896880451 creator A5057082910 @default.
- W2896880451 creator A5059651102 @default.
- W2896880451 creator A5072977312 @default.
- W2896880451 creator A5078607601 @default.
- W2896880451 creator A5084635418 @default.
- W2896880451 date "2018-10-18" @default.
- W2896880451 modified "2023-10-18" @default.
- W2896880451 title "Novel Potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) Injury in Rat Ex-Vivo Heart Model" @default.
- W2896880451 cites W191621842 @default.
- W2896880451 cites W1968107238 @default.
- W2896880451 cites W1971892177 @default.
- W2896880451 cites W1974235853 @default.
- W2896880451 cites W198394325 @default.
- W2896880451 cites W1990398731 @default.
- W2896880451 cites W1995160933 @default.
- W2896880451 cites W1995692886 @default.
- W2896880451 cites W2009611544 @default.
- W2896880451 cites W2011095668 @default.
- W2896880451 cites W2020452164 @default.
- W2896880451 cites W2045139932 @default.
- W2896880451 cites W2053095154 @default.
- W2896880451 cites W2057471044 @default.
- W2896880451 cites W2079628729 @default.
- W2896880451 cites W2086529488 @default.
- W2896880451 cites W2091168313 @default.
- W2896880451 cites W2092670040 @default.
- W2896880451 cites W2094758439 @default.
- W2896880451 cites W2098558953 @default.
- W2896880451 cites W2112706561 @default.
- W2896880451 cites W2116093064 @default.
- W2896880451 cites W2116749190 @default.
- W2896880451 cites W2119416582 @default.
- W2896880451 cites W2125649919 @default.
- W2896880451 cites W2140913003 @default.
- W2896880451 cites W2144819568 @default.
- W2896880451 cites W2146355144 @default.
- W2896880451 cites W2147855451 @default.
- W2896880451 cites W2154595662 @default.
- W2896880451 cites W2159205789 @default.
- W2896880451 cites W2180493360 @default.
- W2896880451 cites W2209425904 @default.
- W2896880451 cites W2214416180 @default.
- W2896880451 cites W2293711954 @default.
- W2896880451 cites W2404234615 @default.
- W2896880451 cites W2725030403 @default.
- W2896880451 cites W2883982204 @default.
- W2896880451 cites W4236396892 @default.
- W2896880451 doi "https://doi.org/10.3390/ijms19103226" @default.
- W2896880451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213995" @default.
- W2896880451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30340421" @default.
- W2896880451 hasPublicationYear "2018" @default.
- W2896880451 type Work @default.
- W2896880451 sameAs 2896880451 @default.
- W2896880451 citedByCount "22" @default.
- W2896880451 countsByYear W28968804512019 @default.
- W2896880451 countsByYear W28968804512020 @default.
- W2896880451 countsByYear W28968804512021 @default.
- W2896880451 countsByYear W28968804512022 @default.
- W2896880451 countsByYear W28968804512023 @default.
- W2896880451 crossrefType "journal-article" @default.
- W2896880451 hasAuthorship W2896880451A5016594705 @default.
- W2896880451 hasAuthorship W2896880451A5023626251 @default.
- W2896880451 hasAuthorship W2896880451A5027702960 @default.
- W2896880451 hasAuthorship W2896880451A5039024324 @default.
- W2896880451 hasAuthorship W2896880451A5050756842 @default.
- W2896880451 hasAuthorship W2896880451A5057082910 @default.
- W2896880451 hasAuthorship W2896880451A5059651102 @default.
- W2896880451 hasAuthorship W2896880451A5072977312 @default.
- W2896880451 hasAuthorship W2896880451A5078607601 @default.
- W2896880451 hasAuthorship W2896880451A5084635418 @default.
- W2896880451 hasBestOaLocation W28968804511 @default.
- W2896880451 hasConcept C118303440 @default.
- W2896880451 hasConcept C126322002 @default.
- W2896880451 hasConcept C134018914 @default.
- W2896880451 hasConcept C155164980 @default.
- W2896880451 hasConcept C160145004 @default.
- W2896880451 hasConcept C163170386 @default.
- W2896880451 hasConcept C170488646 @default.
- W2896880451 hasConcept C170493617 @default.
- W2896880451 hasConcept C185592680 @default.
- W2896880451 hasConcept C2777180221 @default.
- W2896880451 hasConcept C2779284873 @default.
- W2896880451 hasConcept C2779676291 @default.
- W2896880451 hasConcept C2780071552 @default.
- W2896880451 hasConcept C2780114680 @default.
- W2896880451 hasConcept C519581460 @default.
- W2896880451 hasConcept C541997718 @default.
- W2896880451 hasConcept C555293320 @default.
- W2896880451 hasConcept C71924100 @default.
- W2896880451 hasConcept C87649029 @default.
- W2896880451 hasConcept C98274493 @default.