Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896880575> ?p ?o ?g. }
- W2896880575 endingPage "567" @default.
- W2896880575 startingPage "561" @default.
- W2896880575 abstract "Live-cell imaging of cell-surface-associated proteolytic enzymes is crucial to understand their biological roles and functions in both physiological and pathological processes. However, the complexity of the cell membrane environment increases difficulties in specifically investigating targeted proteolytic activities within the microenvironment. Towards this end, a unique, photoremovable, furin-responsive peptide probe that can undergo spatiotemporal control through UV-light illumination has been designed and synthesized to aid in visualizing the activity of a cell-surface-associated protease enzyme, furin, in live cells. Prior to light irradiation, the photolabile moiety, 4,5-dimethoxy-2-nitrobenzyl, in the peptide sequence of the reporter will block furin-like enzymatic hydrolysis, and thus, no fluorescence will be observed. Upon simple light illumination, photolysis will occur, thereby revealing the uncaged peptide probe, which can undergo enzyme hydrolysis and lead to an increase in fluorescence signal; this allows the real-time imaging of endogenous cell-surface-associated furin-like enzyme function in living cells through precise spatial and temporal resolution." @default.
- W2896880575 created "2018-10-26" @default.
- W2896880575 creator A5013272580 @default.
- W2896880575 creator A5020201679 @default.
- W2896880575 creator A5034175275 @default.
- W2896880575 creator A5056143558 @default.
- W2896880575 creator A5064711465 @default.
- W2896880575 creator A5079051689 @default.
- W2896880575 creator A5083716771 @default.
- W2896880575 date "2018-11-28" @default.
- W2896880575 modified "2023-10-16" @default.
- W2896880575 title "Spatiotemporal‐Controlled Reporter for Cell‐Surface Proteolytic Enzyme Activity Visualization" @default.
- W2896880575 cites W1536640324 @default.
- W2896880575 cites W1563019217 @default.
- W2896880575 cites W1570602659 @default.
- W2896880575 cites W1965152120 @default.
- W2896880575 cites W1971356903 @default.
- W2896880575 cites W1973772094 @default.
- W2896880575 cites W1974029263 @default.
- W2896880575 cites W1974043792 @default.
- W2896880575 cites W1979758767 @default.
- W2896880575 cites W1989873976 @default.
- W2896880575 cites W1990501846 @default.
- W2896880575 cites W1991579790 @default.
- W2896880575 cites W1996904453 @default.
- W2896880575 cites W1998535769 @default.
- W2896880575 cites W1999857469 @default.
- W2896880575 cites W2004465970 @default.
- W2896880575 cites W2017916715 @default.
- W2896880575 cites W2018059970 @default.
- W2896880575 cites W2019265324 @default.
- W2896880575 cites W2021144900 @default.
- W2896880575 cites W2025798657 @default.
- W2896880575 cites W2032824001 @default.
- W2896880575 cites W2033439612 @default.
- W2896880575 cites W2042173639 @default.
- W2896880575 cites W2043761213 @default.
- W2896880575 cites W2050520078 @default.
- W2896880575 cites W2059263265 @default.
- W2896880575 cites W2061260000 @default.
- W2896880575 cites W2065209730 @default.
- W2896880575 cites W2069849774 @default.
- W2896880575 cites W2070232478 @default.
- W2896880575 cites W2071174386 @default.
- W2896880575 cites W2071677176 @default.
- W2896880575 cites W2071833952 @default.
- W2896880575 cites W2082230695 @default.
- W2896880575 cites W2086590919 @default.
- W2896880575 cites W2086705938 @default.
- W2896880575 cites W2088270109 @default.
- W2896880575 cites W2089268815 @default.
- W2896880575 cites W2089618131 @default.
- W2896880575 cites W2094222285 @default.
- W2896880575 cites W2096960609 @default.
- W2896880575 cites W2099132605 @default.
- W2896880575 cites W2103850156 @default.
- W2896880575 cites W2104036010 @default.
- W2896880575 cites W2105689679 @default.
- W2896880575 cites W2110747905 @default.
- W2896880575 cites W2115207115 @default.
- W2896880575 cites W2125160663 @default.
- W2896880575 cites W2127986840 @default.
- W2896880575 cites W2133498598 @default.
- W2896880575 cites W2135979308 @default.
- W2896880575 cites W2138734968 @default.
- W2896880575 cites W2146604108 @default.
- W2896880575 cites W2155839956 @default.
- W2896880575 cites W2163594072 @default.
- W2896880575 cites W2226584831 @default.
- W2896880575 cites W2235067608 @default.
- W2896880575 cites W2327829739 @default.
- W2896880575 cites W2443490729 @default.
- W2896880575 cites W2517268210 @default.
- W2896880575 cites W2549641338 @default.
- W2896880575 cites W2783996245 @default.
- W2896880575 cites W4211153221 @default.
- W2896880575 cites W4229857880 @default.
- W2896880575 cites W4233389194 @default.
- W2896880575 cites W4234141882 @default.
- W2896880575 cites W4240226504 @default.
- W2896880575 cites W4242400907 @default.
- W2896880575 cites W4246683947 @default.
- W2896880575 cites W4248650850 @default.
- W2896880575 cites W4255147071 @default.
- W2896880575 cites W80287984 @default.
- W2896880575 doi "https://doi.org/10.1002/cbic.201800445" @default.
- W2896880575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30304583" @default.
- W2896880575 hasPublicationYear "2018" @default.
- W2896880575 type Work @default.
- W2896880575 sameAs 2896880575 @default.
- W2896880575 citedByCount "6" @default.
- W2896880575 countsByYear W28968805752020 @default.
- W2896880575 countsByYear W28968805752021 @default.
- W2896880575 countsByYear W28968805752022 @default.
- W2896880575 crossrefType "journal-article" @default.
- W2896880575 hasAuthorship W2896880575A5013272580 @default.
- W2896880575 hasAuthorship W2896880575A5020201679 @default.
- W2896880575 hasAuthorship W2896880575A5034175275 @default.