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- W2896880944 abstract "Significance Our findings shift the paradigm of NRF2 as a transcriptional activator to one in which NRF2 can also act as a transcriptional repressor, which we believe will stimulate new research areas and interests among scientists from other fields. While the majority of the data provided in this paper center on suppression of MYLK expression and the resulting pathological significance, the more far-reaching findings are the in silico and RNA-seq datasets indicating that the NRF2-replication protein A1 (RPA1)-ARE-NRE complex transcriptionally represses other genes as well, again highlighting the broad scope and significance of NRF2 repression of target genes." @default.
- W2896880944 created "2018-10-26" @default.
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- W2896880944 date "2018-10-11" @default.
- W2896880944 modified "2023-10-02" @default.
- W2896880944 title "RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE–dependent repression" @default.
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- W2896880944 doi "https://doi.org/10.1073/pnas.1812125115" @default.
- W2896880944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6217430" @default.
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