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- W2896884572 abstract "YidC proteins are membrane-localized chaperone insertases that are universally conserved in all bacteria and are traditionally studied in the context of membrane protein insertion and assembly. Both YidC paralogs of the cariogenic pathogen Streptococcus mutans are required for proper envelope biogenesis and full virulence, indicating that these proteins may also contribute to optimal biofilm formation in streptococci. Here, we show that the deletion of either yidC results in changes to the structure and physical properties of the EPS matrix produced by S. mutans , ultimately impairing optimal biofilm development, diminishing its mechanical stability, and facilitating its removal. Importantly, the universal conservation of bacterial yidC orthologs, combined with our findings, provide a rationale for YidC as a possible drug target for antibiofilm therapies." @default.
- W2896884572 created "2018-10-26" @default.
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- W2896884572 date "2019-01-01" @default.
- W2896884572 modified "2023-10-11" @default.
- W2896884572 title "<i>Streptococcus mutans yidC1</i> and <i>yidC2</i> Impact Cell Envelope Biogenesis, the Biofilm Matrix, and Biofilm Biophysical Properties" @default.
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- W2896884572 doi "https://doi.org/10.1128/jb.00396-18" @default.
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