FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896886233> ?p ?o ?g. }

• W2896886233 abstract "Cardiovascular benefits by reversing environmental risks factors for essential hypertension (EH) and dyslipidemia could be weaken by high genetic risk. We investigated possible associations between ACE2 polymorphisms and dyslipidemia in patients with EH. Four hundred and two hypertensive patients were enrolled in an EH group and 233 normotensive individuals were enrolled as control group from the Xinjiang region of China. Fourteen ACE2 polymorphisms were genotyped by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Participants carrying T allele (TT + CT) of rs2074192 (P = 0.006), rs4646155 (P = 0.030) and rs4646188 (P < 0.001), C allele (CT + CT or CC + CG) of rs4240157 (P = 0.012), rs4830542 (P = 0.020) and rs879922 (P < 0.001) and TT genotype of rs2106809 (P = 0.012) were associated with EH. Meanwhile,ACE2 SNPs also exhibited association with dyslipidemia but exhibited obvious heterogeneity. rs1978124 (TT + CT, P = 0.009), rs2106809 (TT, P = 0.045), rs233575 (CC + CT, P = 0.018), rs4646188 (CC, P = 0.011) and rs879922 (CC + CG, P = 0.003) were association with increased LDL-C (≥1.8 mmol/L). rs2106809 (CC + CT, P < 0.001), rs2285666(TT + CT, P = 0.017), rs4646142(CC + CG, P = 0.044), rs4646155(TT + CT, P < 0.001) and rs4646188(TT + CT, P = 0.033) were association with decreased HDL-C (< 1.0 mmol/L). rs2074192 (TT + CT, P = 0.012), rs4240157 (CC + CT, P = 0.027), rs4646156 (AA+AT, P = 0.007), rs4646188 (TT + CT, P = 0.005), rs4830542 (CC + CT, P = 0.047) and rs879922 (CC + CG, P = 0.001) were association with increased TC (≥5.2 mmol/L). rs2106809 (P = 0.034) and rs4646188 (P = 0.013) were associated with hypertriglyceridemia. Further, ischemic stroke was more prevalent with rs4240157 (CC + CT, P = 0.043), rs4646188 (CC + CT, P = 0.013) and rs4830542 (CC + CT, P = 0.037). In addition, rs2048683 and rs6632677 were not association with EH, dyslipidemia and ischemic stroke. The ACE2 rs4646188 variant may be a potential and optimal genetic susceptibility marker for EH, dyslipidemia and its related ischemic stroke." @default.
• W2896886233 created "2018-10-26" @default.
• W2896886233 creator A5015069162 @default.
• W2896886233 creator A5030131824 @default.
• W2896886233 creator A5042026897 @default.
• W2896886233 creator A5043219536 @default.
• W2896886233 creator A5044650830 @default.
• W2896886233 creator A5045610083 @default.
• W2896886233 creator A5047697862 @default.
• W2896886233 creator A5047916176 @default.
• W2896886233 creator A5051149614 @default.
• W2896886233 creator A5054121557 @default.
• W2896886233 creator A5068242622 @default.
• W2896886233 date "2018-10-20" @default.
• W2896886233 modified "2023-10-18" @default.
• W2896886233 title "Association of ACE2 polymorphisms with susceptibility to essential hypertension and dyslipidemia in Xinjiang, China" @default.
• W2896886233 cites W1480729244 @default.
• W2896886233 cites W182112830 @default.
• W2896886233 cites W1967017107 @default.
• W2896886233 cites W1968181432 @default.
• W2896886233 cites W1970493260 @default.
• W2896886233 cites W1979488003 @default.
• W2896886233 cites W1992404999 @default.
• W2896886233 cites W2001758255 @default.
• W2896886233 cites W2020512792 @default.
• W2896886233 cites W2025072503 @default.
• W2896886233 cites W2037927640 @default.
• W2896886233 cites W2040536071 @default.
• W2896886233 cites W2094058624 @default.
• W2896886233 cites W2098099928 @default.
• W2896886233 cites W2101300620 @default.
• W2896886233 cites W2103849921 @default.
• W2896886233 cites W2104103470 @default.
• W2896886233 cites W2109740270 @default.
• W2896886233 cites W2111099202 @default.
• W2896886233 cites W2116047107 @default.
• W2896886233 cites W2116198171 @default.
• W2896886233 cites W2122613362 @default.
• W2896886233 cites W2124247204 @default.
• W2896886233 cites W2125065061 @default.
• W2896886233 cites W2143610863 @default.
• W2896886233 cites W2146704860 @default.
• W2896886233 cites W2157700550 @default.
• W2896886233 cites W2188644540 @default.
• W2896886233 cites W2296834751 @default.
• W2896886233 cites W2337247222 @default.
• W2896886233 cites W2344591421 @default.
• W2896886233 cites W2402335931 @default.
• W2896886233 cites W2409181047 @default.
• W2896886233 cites W2441391782 @default.
• W2896886233 cites W2467869866 @default.
• W2896886233 cites W2503450476 @default.
• W2896886233 cites W2509676484 @default.
• W2896886233 cites W2586320696 @default.
• W2896886233 cites W2606878336 @default.
• W2896886233 cites W2609543937 @default.
• W2896886233 cites W2736366633 @default.
• W2896886233 cites W2737553434 @default.
• W2896886233 cites W2753051611 @default.
• W2896886233 cites W2755474558 @default.
• W2896886233 cites W2777641772 @default.
• W2896886233 cites W2785693876 @default.
• W2896886233 cites W2789687647 @default.
• W2896886233 cites W2791275456 @default.
• W2896886233 cites W2793955071 @default.
• W2896886233 cites W2882972976 @default.
• W2896886233 cites W2981905982 @default.
• W2896886233 doi "https://doi.org/10.1186/s12944-018-0890-6" @default.
• W2896886233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195726" @default.
• W2896886233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30342552" @default.
• W2896886233 hasPublicationYear "2018" @default.
• W2896886233 type Work @default.
• W2896886233 sameAs 2896886233 @default.
• W2896886233 citedByCount "50" @default.
• W2896886233 countsByYear W28968862332019 @default.
• W2896886233 countsByYear W28968862332020 @default.
• W2896886233 countsByYear W28968862332021 @default.
• W2896886233 countsByYear W28968862332022 @default.
• W2896886233 countsByYear W28968862332023 @default.
• W2896886233 crossrefType "journal-article" @default.
• W2896886233 hasAuthorship W2896886233A5015069162 @default.
• W2896886233 hasAuthorship W2896886233A5030131824 @default.
• W2896886233 hasAuthorship W2896886233A5042026897 @default.
• W2896886233 hasAuthorship W2896886233A5043219536 @default.
• W2896886233 hasAuthorship W2896886233A5044650830 @default.
• W2896886233 hasAuthorship W2896886233A5045610083 @default.
• W2896886233 hasAuthorship W2896886233A5047697862 @default.
• W2896886233 hasAuthorship W2896886233A5047916176 @default.
• W2896886233 hasAuthorship W2896886233A5051149614 @default.
• W2896886233 hasAuthorship W2896886233A5054121557 @default.
• W2896886233 hasAuthorship W2896886233A5068242622 @default.
• W2896886233 hasBestOaLocation W28968862331 @default.
• W2896886233 hasConcept C104317684 @default.
• W2896886233 hasConcept C126322002 @default.
• W2896886233 hasConcept C134018914 @default.
• W2896886233 hasConcept C135763542 @default.
• W2896886233 hasConcept C148257392 @default.
• W2896886233 hasConcept C153209595 @default.
• W2896886233 hasConcept C22894154 @default.
• W2896886233 hasConcept C2777097880 @default.

• next