FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896890222> ?p ?o ?g. }

• W2896890222 abstract "Tandem mass tag (TMT)-based quantitation is a strong modality for quantitative proteomics, as samples can be multiplexed, creating large-scale data sets with high precision and minimal missing values. However, coisolation/cofragmentation of near isobaric, coeluting precursor peptide analytes has been well-documented to show ratio compression, compromising the accuracy of peptide/protein quantitation. Advanced peak determination (APD) is a new peak-picking algorithm that shows improved identification of peak detection in survey scans (MS1) to increase the number of precursors selected for unimolecular dissociation (MS2). To increase the number of these “features” selected for MS2 APD purposefully selects multiple peptide precursors of very similar m/z that often derive from different proteins—a major source of ratio compression in TMT quantification. Here, we evaluate the effects of various data acquisition parameters combined with APD on ratio compression. We find that data acquisition with APD enabled results in more coisolated precursors, more mixed spectra, and in turn, fewer peptide spectral matches, especially at standard on-column loads. We conclude that APD should not be utilized for isobaric tagging, MS2-based experiments." @default.
• W2896890222 created "2018-10-26" @default.
• W2896890222 creator A5006801972 @default.
• W2896890222 creator A5009221258 @default.
• W2896890222 creator A5012518351 @default.
• W2896890222 creator A5026162401 @default.
• W2896890222 creator A5028040253 @default.
• W2896890222 creator A5032974629 @default.
• W2896890222 creator A5036255260 @default.
• W2896890222 creator A5047260313 @default.
• W2896890222 creator A5082586608 @default.
• W2896890222 date "2018-10-31" @default.
• W2896890222 modified "2023-09-24" @default.
• W2896890222 title "Evaluation of Advanced Precursor Determination for Tandem Mass Tag (TMT)-Based Quantitative Proteomics across Instrument Platforms" @default.
• W2896890222 cites W1964560975 @default.
• W2896890222 cites W1986656413 @default.
• W2896890222 cites W1988146323 @default.
• W2896890222 cites W1988811003 @default.
• W2896890222 cites W1999556153 @default.
• W2896890222 cites W2011710911 @default.
• W2896890222 cites W2012626734 @default.
• W2896890222 cites W2048280438 @default.
• W2896890222 cites W2069684499 @default.
• W2896890222 cites W2149107649 @default.
• W2896890222 cites W2150981032 @default.
• W2896890222 cites W2395887422 @default.
• W2896890222 cites W2461644695 @default.
• W2896890222 cites W2604924504 @default.
• W2896890222 cites W2778601930 @default.
• W2896890222 cites W2789810162 @default.
• W2896890222 cites W2798133595 @default.
• W2896890222 cites W2799616694 @default.
• W2896890222 doi "https://doi.org/10.1021/acs.jproteome.8b00611" @default.
• W2896890222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30351145" @default.
• W2896890222 hasPublicationYear "2018" @default.
• W2896890222 type Work @default.
• W2896890222 sameAs 2896890222 @default.
• W2896890222 citedByCount "14" @default.
• W2896890222 countsByYear W28968902222018 @default.
• W2896890222 countsByYear W28968902222019 @default.
• W2896890222 countsByYear W28968902222020 @default.
• W2896890222 countsByYear W28968902222021 @default.
• W2896890222 countsByYear W28968902222022 @default.
• W2896890222 countsByYear W28968902222023 @default.
• W2896890222 crossrefType "journal-article" @default.
• W2896890222 hasAuthorship W2896890222A5006801972 @default.
• W2896890222 hasAuthorship W2896890222A5009221258 @default.
• W2896890222 hasAuthorship W2896890222A5012518351 @default.
• W2896890222 hasAuthorship W2896890222A5026162401 @default.
• W2896890222 hasAuthorship W2896890222A5028040253 @default.
• W2896890222 hasAuthorship W2896890222A5032974629 @default.
• W2896890222 hasAuthorship W2896890222A5036255260 @default.
• W2896890222 hasAuthorship W2896890222A5047260313 @default.
• W2896890222 hasAuthorship W2896890222A5082586608 @default.
• W2896890222 hasConcept C10390740 @default.
• W2896890222 hasConcept C104317684 @default.
• W2896890222 hasConcept C113196181 @default.
• W2896890222 hasConcept C121332964 @default.
• W2896890222 hasConcept C146211579 @default.
• W2896890222 hasConcept C159985019 @default.
• W2896890222 hasConcept C162356407 @default.
• W2896890222 hasConcept C184185385 @default.
• W2896890222 hasConcept C185592680 @default.
• W2896890222 hasConcept C192562407 @default.
• W2896890222 hasConcept C202157981 @default.
• W2896890222 hasConcept C2777814067 @default.
• W2896890222 hasConcept C2779281246 @default.
• W2896890222 hasConcept C31827203 @default.
• W2896890222 hasConcept C41008148 @default.
• W2896890222 hasConcept C43617362 @default.
• W2896890222 hasConcept C46111723 @default.
• W2896890222 hasConcept C55493867 @default.
• W2896890222 hasConcept C73090800 @default.
• W2896890222 hasConcept C80311884 @default.
• W2896890222 hasConcept C86153913 @default.
• W2896890222 hasConcept C97355855 @default.
• W2896890222 hasConceptScore W2896890222C10390740 @default.
• W2896890222 hasConceptScore W2896890222C104317684 @default.
• W2896890222 hasConceptScore W2896890222C113196181 @default.
• W2896890222 hasConceptScore W2896890222C121332964 @default.
• W2896890222 hasConceptScore W2896890222C146211579 @default.
• W2896890222 hasConceptScore W2896890222C159985019 @default.
• W2896890222 hasConceptScore W2896890222C162356407 @default.
• W2896890222 hasConceptScore W2896890222C184185385 @default.
• W2896890222 hasConceptScore W2896890222C185592680 @default.
• W2896890222 hasConceptScore W2896890222C192562407 @default.
• W2896890222 hasConceptScore W2896890222C202157981 @default.
• W2896890222 hasConceptScore W2896890222C2777814067 @default.
• W2896890222 hasConceptScore W2896890222C2779281246 @default.
• W2896890222 hasConceptScore W2896890222C31827203 @default.
• W2896890222 hasConceptScore W2896890222C41008148 @default.
• W2896890222 hasConceptScore W2896890222C43617362 @default.
• W2896890222 hasConceptScore W2896890222C46111723 @default.
• W2896890222 hasConceptScore W2896890222C55493867 @default.
• W2896890222 hasConceptScore W2896890222C73090800 @default.
• W2896890222 hasConceptScore W2896890222C80311884 @default.
• W2896890222 hasConceptScore W2896890222C86153913 @default.
• W2896890222 hasConceptScore W2896890222C97355855 @default.
• W2896890222 hasFunder F4320337351 @default.
• W2896890222 hasLocation W28968902221 @default.

• next