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- W2896891646 abstract "Simultaneous assessment of motor and cognitive “dual tasks” has been demonstrated as a promising method to identify the cognitive status of older adults. Our objective was to develop a novel dual-task cognitive function test incorporating a validated gait equivalent upper-extremity function (UEF) test simultaneously performed with counting backwards as a cognitive challenge. Older adults (≥65 years) were recruited and stratified into three clinically confirmed groups: 1) cognitively healthy (CN), 2) mild cognitive impairment (MCI), and 3) early Alzheimer's disease (AD). Elbow angular velocity was measured using three-dimensional gyroscopes attached to the wrist and upper-arm. Participants completed six trials of single-task and dual-task UEF at two elbow flexion speeds (rapid and self-paced) and three cognitive counting tasks (no counting, backwards by ones, and backwards by threes). The outcome of interest was motor function performance (coefficient of variation between flexion time intervals to assess pauses/delays in motor task execution) per condition. Between group comparisons were made using ANCOVA models while controlling for age, sex, and body mass index. Subsequently, the UEF condition with the highest effect size was used in an ordinal logistic model for group discrimination. Thirty participants were recruited (10 CN: age=86.3±2.9, 10 MCI: age=87.2±3.0, and 10 AD: age=86.5±5.3). ANCOVA models showed significant associations between cognition groups and elbow flexion variability in all four dual-task conditions (p<0.04; effect size=0.57-1.47). The highest effect size was observed for self-paced plus counting backward by one, with variability coefficients 10±5%, 16±14%, and 50±17% for CN, MCI, and AD groups, respectively. Using this same single motor task variability parameter (self-paced and counting backward by one) in a logistic model, MCI and AD group assignment was predicted with a receiver operating characteristic area under the curve of 0.82 and 0.97, respectively. Accurate, objective, and rapid cognition screening strategies are needed for use in research and clinical settings. The reported method has high screening potential, and could be likewise employed to measure change over time. Our preliminary findings should be further explored in a larger study." @default.
- W2896891646 created "2018-10-26" @default.
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- W2896891646 date "2018-07-01" @default.
- W2896891646 modified "2023-10-16" @default.
- W2896891646 title "TD‐P‐013: ASSESSMENT OF DUAL‐TASK MOTOR FUNCTION DETERIORATION FOR DETECTING COGNITIVE IMPAIRMENT" @default.
- W2896891646 doi "https://doi.org/10.1016/j.jalz.2018.06.2029" @default.
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