FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896899648> ?p ?o ?g. }

• W2896899648 endingPage "853" @default.
• W2896899648 startingPage "845" @default.
• W2896899648 abstract "Background: Adequate selection of patients with peritoneal metastasis (PM) for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remains critical for successful long-term outcomes. Factors reflecting tumor biology are currently poorly represented in the selection process. The prognostic relevance of RAS/RAF mutations in patients with PM remains unclear. Methods: Survival data of patients with colorectal PM operated in 6 European tertiary centers were retrospectively collected and predictive factors for survival identified by Cox regression analyses. A simple point-based risk score was developed to allow patient selection and outcome prediction. Results: Data of 524 patients with a median age of 59 years and a median peritoneal cancer index of 7 (interquartile range: 3–12) were collected. A complete resection was possible in 505 patients; overall morbidity and 90-day mortality were 50.9% and 2.1%, respectively. PCI [hazard ratio (HR): 1.08], N1 stage (HR: 2.15), N2 stage (HR: 2.57), G3 stage (HR: 1.80) as well as KRAS (HR: 1.46) and BRAF (HR: 3.97) mutations were found to significantly impair survival after CRS/HIPEC on multivariate analyses. Mutations of RAS/RAF impaired survival independently of targeted treatment against EGFR. Consequently, a simple point-based risk score termed BIOSCOPE (BIOlogical Score of COlorectal PEritoneal metastasis) based on PCI, N-, G-, and RAS/RAF status was developed, which showed good discrimination [development area under the curve (AUC) = 0.72, validation AUC = 0.70], calibration ( P = 0.401) and allowed categorization of patients into 4 groups with strongly divergent survival outcomes. Conclusion: RAS/RAF mutations impair survival after CRS/HIPEC. The novel BIOSCOPE score reflects tumor biology, adequately stratifies long-term outcomes, and improves patient assessment and selection." @default.
• W2896899648 created "2018-10-26" @default.
• W2896899648 creator A5000959298 @default.
• W2896899648 creator A5001148990 @default.
• W2896899648 creator A5002700427 @default.
• W2896899648 creator A5003980490 @default.
• W2896899648 creator A5008642365 @default.
• W2896899648 creator A5017245457 @default.
• W2896899648 creator A5017644856 @default.
• W2896899648 creator A5020723600 @default.
• W2896899648 creator A5022131781 @default.
• W2896899648 creator A5030548090 @default.
• W2896899648 creator A5031036666 @default.
• W2896899648 creator A5031336882 @default.
• W2896899648 creator A5044511086 @default.
• W2896899648 creator A5051847650 @default.
• W2896899648 creator A5069670123 @default.
• W2896899648 creator A5081201185 @default.
• W2896899648 creator A5082747013 @default.
• W2896899648 creator A5090081694 @default.
• W2896899648 date "2018-11-01" @default.
• W2896899648 modified "2023-09-30" @default.
• W2896899648 title "Mutations of RAS/RAF Proto-oncogenes Impair Survival After Cytoreductive Surgery and HIPEC for Peritoneal Metastasis of Colorectal Origin" @default.
• W2896899648 cites W1535319703 @default.
• W2896899648 cites W1985035689 @default.
• W2896899648 cites W2005524485 @default.
• W2896899648 cites W2014449122 @default.
• W2896899648 cites W2019393736 @default.
• W2896899648 cites W2037195555 @default.
• W2896899648 cites W2038624343 @default.
• W2896899648 cites W2049282019 @default.
• W2896899648 cites W2052184097 @default.
• W2896899648 cites W2057155604 @default.
• W2896899648 cites W2084346269 @default.
• W2896899648 cites W2084994096 @default.
• W2896899648 cites W2095201384 @default.
• W2896899648 cites W2096998881 @default.
• W2896899648 cites W2098026442 @default.
• W2896899648 cites W2114545185 @default.
• W2896899648 cites W2127231441 @default.
• W2896899648 cites W2132432664 @default.
• W2896899648 cites W2142564546 @default.
• W2896899648 cites W2144026118 @default.
• W2896899648 cites W2147993276 @default.
• W2896899648 cites W2151456396 @default.
• W2896899648 cites W2157824687 @default.
• W2896899648 cites W2159124192 @default.
• W2896899648 cites W2165976417 @default.
• W2896899648 cites W2169242405 @default.
• W2896899648 cites W2208255722 @default.
• W2896899648 cites W2234879572 @default.
• W2896899648 cites W2301065828 @default.
• W2896899648 cites W2309451803 @default.
• W2896899648 cites W2329882089 @default.
• W2896899648 cites W2409420104 @default.
• W2896899648 cites W2531203326 @default.
• W2896899648 cites W2593829893 @default.
• W2896899648 cites W2754920657 @default.
• W2896899648 cites W2782955211 @default.
• W2896899648 cites W4385789423 @default.
• W2896899648 doi "https://doi.org/10.1097/sla.0000000000002899" @default.
• W2896899648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30303876" @default.
• W2896899648 hasPublicationYear "2018" @default.
• W2896899648 type Work @default.
• W2896899648 sameAs 2896899648 @default.
• W2896899648 citedByCount "80" @default.
• W2896899648 countsByYear W28968996482019 @default.
• W2896899648 countsByYear W28968996482020 @default.
• W2896899648 countsByYear W28968996482021 @default.
• W2896899648 countsByYear W28968996482022 @default.
• W2896899648 countsByYear W28968996482023 @default.
• W2896899648 crossrefType "journal-article" @default.
• W2896899648 hasAuthorship W2896899648A5000959298 @default.
• W2896899648 hasAuthorship W2896899648A5001148990 @default.
• W2896899648 hasAuthorship W2896899648A5002700427 @default.
• W2896899648 hasAuthorship W2896899648A5003980490 @default.
• W2896899648 hasAuthorship W2896899648A5008642365 @default.
• W2896899648 hasAuthorship W2896899648A5017245457 @default.
• W2896899648 hasAuthorship W2896899648A5017644856 @default.
• W2896899648 hasAuthorship W2896899648A5020723600 @default.
• W2896899648 hasAuthorship W2896899648A5022131781 @default.
• W2896899648 hasAuthorship W2896899648A5030548090 @default.
• W2896899648 hasAuthorship W2896899648A5031036666 @default.
• W2896899648 hasAuthorship W2896899648A5031336882 @default.
• W2896899648 hasAuthorship W2896899648A5044511086 @default.
• W2896899648 hasAuthorship W2896899648A5051847650 @default.
• W2896899648 hasAuthorship W2896899648A5069670123 @default.
• W2896899648 hasAuthorship W2896899648A5081201185 @default.
• W2896899648 hasAuthorship W2896899648A5082747013 @default.
• W2896899648 hasAuthorship W2896899648A5090081694 @default.
• W2896899648 hasBestOaLocation W28968996482 @default.
• W2896899648 hasConcept C10515644 @default.
• W2896899648 hasConcept C119060515 @default.
• W2896899648 hasConcept C121608353 @default.
• W2896899648 hasConcept C126322002 @default.
• W2896899648 hasConcept C141071460 @default.
• W2896899648 hasConcept C143998085 @default.
• W2896899648 hasConcept C146357865 @default.

• next