FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896903792> ?p ?o ?g. }

• W2896903792 endingPage "143" @default.
• W2896903792 startingPage "134" @default.
• W2896903792 abstract "Alternative splicing is a regulatory mechanism by which multiple mRNA isoforms are generated from single genes. Numerous genes that encode membrane trafficking proteins are alternatively spliced. However, there is limited information about the functional consequences that result from these splicing transitions. Here, we developed appropriate tools to study the functional impact of alternative splicing in development within the most in vivo context. Secondly, we provided evidence of the physiological implications of splicing regulation during muscle development. Our previous work in mouse heart development identified three trafficking genes that are regulated by alternative splicing between birth and adulthood: the clathrin heavy chain, the clathrin light chain-a, and the trafficking kinesin binding protein-1. Here, we demonstrated that alternative splicing regulation of these three genes is tissue- and developmental stage-specific. To identify the functional consequences of splicing regulation in vivo, we used genome editing to block the neonatal-to-adult splicing transitions. We characterized the phenotype of one of these mouse lines and demonstrated that when splicing regulation of the clathrin heavy chain gene is prevented mice exhibit an increase in body and muscle weights which is due to an enlargement in myofiber size. The significance of this work has two components. First, we revealed novel roles of the clathrin heavy chain in muscle growth and showed that its regulation by alternative splicing contributes to muscle development. Second, the new mouse lines will provide a useful tool to study how splicing regulation of three trafficking genes affects tissue identity acquisition and maturation in vivo." @default.
• W2896903792 created "2018-10-26" @default.
• W2896903792 creator A5013019099 @default.
• W2896903792 creator A5024523700 @default.
• W2896903792 creator A5046546707 @default.
• W2896903792 creator A5049191443 @default.
• W2896903792 creator A5078908482 @default.
• W2896903792 date "2018-12-01" @default.
• W2896903792 modified "2023-10-17" @default.
• W2896903792 title "Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology" @default.
• W2896903792 cites W1596376323 @default.
• W2896903792 cites W1816723290 @default.
• W2896903792 cites W1991744562 @default.
• W2896903792 cites W2002669455 @default.
• W2896903792 cites W2010136740 @default.
• W2896903792 cites W2011920499 @default.
• W2896903792 cites W2024316397 @default.
• W2896903792 cites W2043700309 @default.
• W2896903792 cites W2047623759 @default.
• W2896903792 cites W2047920353 @default.
• W2896903792 cites W2053911894 @default.
• W2896903792 cites W2101870777 @default.
• W2896903792 cites W2120468192 @default.
• W2896903792 cites W2123179937 @default.
• W2896903792 cites W2136509538 @default.
• W2896903792 cites W2139480055 @default.
• W2896903792 cites W2140191008 @default.
• W2896903792 cites W2145089843 @default.
• W2896903792 cites W2155804510 @default.
• W2896903792 cites W2156126895 @default.
• W2896903792 cites W2400490700 @default.
• W2896903792 cites W2419135488 @default.
• W2896903792 cites W2546746451 @default.
• W2896903792 cites W2554224355 @default.
• W2896903792 cites W2603655183 @default.
• W2896903792 cites W2607400005 @default.
• W2896903792 cites W2612976808 @default.
• W2896903792 cites W2716005210 @default.
• W2896903792 cites W2754169530 @default.
• W2896903792 cites W2804490297 @default.
• W2896903792 cites W2804840673 @default.
• W2896903792 doi "https://doi.org/10.1016/j.biocel.2018.10.004" @default.
• W2896903792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6289647" @default.
• W2896903792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30316870" @default.
• W2896903792 hasPublicationYear "2018" @default.
• W2896903792 type Work @default.
• W2896903792 sameAs 2896903792 @default.
• W2896903792 citedByCount "6" @default.
• W2896903792 countsByYear W28969037922018 @default.
• W2896903792 countsByYear W28969037922020 @default.
• W2896903792 countsByYear W28969037922021 @default.
• W2896903792 countsByYear W28969037922022 @default.
• W2896903792 crossrefType "journal-article" @default.
• W2896903792 hasAuthorship W2896903792A5013019099 @default.
• W2896903792 hasAuthorship W2896903792A5024523700 @default.
• W2896903792 hasAuthorship W2896903792A5046546707 @default.
• W2896903792 hasAuthorship W2896903792A5049191443 @default.
• W2896903792 hasAuthorship W2896903792A5078908482 @default.
• W2896903792 hasBestOaLocation W28969037922 @default.
• W2896903792 hasConcept C104317684 @default.
• W2896903792 hasConcept C1491633281 @default.
• W2896903792 hasConcept C194583182 @default.
• W2896903792 hasConcept C28005876 @default.
• W2896903792 hasConcept C40000846 @default.
• W2896903792 hasConcept C53345823 @default.
• W2896903792 hasConcept C54355233 @default.
• W2896903792 hasConcept C54458228 @default.
• W2896903792 hasConcept C63162447 @default.
• W2896903792 hasConcept C67705224 @default.
• W2896903792 hasConcept C70721500 @default.
• W2896903792 hasConcept C86803240 @default.
• W2896903792 hasConcept C95444343 @default.
• W2896903792 hasConceptScore W2896903792C104317684 @default.
• W2896903792 hasConceptScore W2896903792C1491633281 @default.
• W2896903792 hasConceptScore W2896903792C194583182 @default.
• W2896903792 hasConceptScore W2896903792C28005876 @default.
• W2896903792 hasConceptScore W2896903792C40000846 @default.
• W2896903792 hasConceptScore W2896903792C53345823 @default.
• W2896903792 hasConceptScore W2896903792C54355233 @default.
• W2896903792 hasConceptScore W2896903792C54458228 @default.
• W2896903792 hasConceptScore W2896903792C63162447 @default.
• W2896903792 hasConceptScore W2896903792C67705224 @default.
• W2896903792 hasConceptScore W2896903792C70721500 @default.
• W2896903792 hasConceptScore W2896903792C86803240 @default.
• W2896903792 hasConceptScore W2896903792C95444343 @default.
• W2896903792 hasFunder F4320332161 @default.
• W2896903792 hasFunder F4320337357 @default.
• W2896903792 hasLocation W28969037921 @default.
• W2896903792 hasLocation W28969037922 @default.
• W2896903792 hasLocation W28969037923 @default.
• W2896903792 hasLocation W28969037924 @default.
• W2896903792 hasOpenAccess W2896903792 @default.
• W2896903792 hasPrimaryLocation W28969037921 @default.
• W2896903792 hasRelatedWork W1753947244 @default.
• W2896903792 hasRelatedWork W2008117561 @default.
• W2896903792 hasRelatedWork W2041399050 @default.
• W2896903792 hasRelatedWork W2227731780 @default.
• W2896903792 hasRelatedWork W2514652530 @default.

• next