FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896906720> ?p ?o ?g. }

• W2896906720 endingPage "e1002670" @default.
• W2896906720 startingPage "e1002670" @default.
• W2896906720 abstract "Background We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D). Methods and findings Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance–weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, triglycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73–0.87); of 17:0, 0.65 (0.59–0.72); of t16:1n7, 0.82 (0.70–0.96); and of their sum, 0.71 (0.63–0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men (pinteraction < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist. Conclusions In a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D." @default.
• W2896906720 created "2018-10-26" @default.
• W2896906720 creator A5000325789 @default.
• W2896906720 creator A5003187056 @default.
• W2896906720 creator A5004395330 @default.
• W2896906720 creator A5008751750 @default.
• W2896906720 creator A5009187711 @default.
• W2896906720 creator A5009270847 @default.
• W2896906720 creator A5010501927 @default.
• W2896906720 creator A5010882609 @default.
• W2896906720 creator A5012520344 @default.
• W2896906720 creator A5013519955 @default.
• W2896906720 creator A5015851170 @default.
• W2896906720 creator A5016270945 @default.
• W2896906720 creator A5017572190 @default.
• W2896906720 creator A5019133187 @default.
• W2896906720 creator A5019717682 @default.
• W2896906720 creator A5021882942 @default.
• W2896906720 creator A5024313662 @default.
• W2896906720 creator A5026461159 @default.
• W2896906720 creator A5029677986 @default.
• W2896906720 creator A5035565535 @default.
• W2896906720 creator A5038743007 @default.
• W2896906720 creator A5040379606 @default.
• W2896906720 creator A5042973809 @default.
• W2896906720 creator A5049065024 @default.
• W2896906720 creator A5049145809 @default.
• W2896906720 creator A5049309182 @default.
• W2896906720 creator A5050606354 @default.
• W2896906720 creator A5052530176 @default.
• W2896906720 creator A5053145763 @default.
• W2896906720 creator A5056459536 @default.
• W2896906720 creator A5056667597 @default.
• W2896906720 creator A5063220095 @default.
• W2896906720 creator A5064305841 @default.
• W2896906720 creator A5064683267 @default.
• W2896906720 creator A5064987258 @default.
• W2896906720 creator A5066049666 @default.
• W2896906720 creator A5070324150 @default.
• W2896906720 creator A5073734270 @default.
• W2896906720 creator A5074400322 @default.
• W2896906720 creator A5074466135 @default.
• W2896906720 creator A5075177822 @default.
• W2896906720 creator A5076349029 @default.
• W2896906720 creator A5083800496 @default.
• W2896906720 creator A5085771050 @default.
• W2896906720 creator A5087655712 @default.
• W2896906720 creator A5089418361 @default.
• W2896906720 creator A5089623919 @default.
• W2896906720 creator A5089957643 @default.
• W2896906720 date "2018-10-10" @default.
• W2896906720 modified "2023-10-17" @default.
• W2896906720 title "Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies" @default.
• W2896906720 cites W1541608094 @default.
• W2896906720 cites W1849396925 @default.
• W2896906720 cites W1962574364 @default.
• W2896906720 cites W1964675575 @default.
• W2896906720 cites W1993540550 @default.
• W2896906720 cites W1995856488 @default.
• W2896906720 cites W2002364623 @default.
• W2896906720 cites W2006381997 @default.
• W2896906720 cites W2022142180 @default.
• W2896906720 cites W2026310866 @default.
• W2896906720 cites W2028647952 @default.
• W2896906720 cites W2031164172 @default.
• W2896906720 cites W2031521765 @default.
• W2896906720 cites W2053307994 @default.
• W2896906720 cites W2062498197 @default.
• W2896906720 cites W2064176291 @default.
• W2896906720 cites W2074079685 @default.
• W2896906720 cites W2075341416 @default.
• W2896906720 cites W2098825532 @default.
• W2896906720 cites W2104370986 @default.
• W2896906720 cites W2105087123 @default.
• W2896906720 cites W2109060632 @default.
• W2896906720 cites W2125895299 @default.
• W2896906720 cites W2126930838 @default.
• W2896906720 cites W2131996809 @default.
• W2896906720 cites W2134210047 @default.
• W2896906720 cites W2139021653 @default.
• W2896906720 cites W2139255321 @default.
• W2896906720 cites W2141759136 @default.
• W2896906720 cites W2146237755 @default.
• W2896906720 cites W2151042915 @default.
• W2896906720 cites W2154278990 @default.
• W2896906720 cites W2166953117 @default.
• W2896906720 cites W2168530080 @default.
• W2896906720 cites W2208829852 @default.
• W2896906720 cites W2273827122 @default.
• W2896906720 cites W2285624860 @default.
• W2896906720 cites W2333420755 @default.
• W2896906720 cites W2344448972 @default.
• W2896906720 cites W2433511304 @default.
• W2896906720 cites W2465177485 @default.
• W2896906720 cites W2469860611 @default.
• W2896906720 cites W2539376600 @default.
• W2896906720 cites W2555125137 @default.
• W2896906720 cites W2559593242 @default.

• next