FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896909115> ?p ?o ?g. }

• W2896909115 endingPage "6356" @default.
• W2896909115 startingPage "6345" @default.
• W2896909115 abstract "Abstract 4‐O‐methylascochlorin ( MAC ) is a derivative of ascochlorin, a prenyl‐phenol compound antibiotic isolated from the fungus Ascochyta viciae . MAC induces caspase/poly (ADP‐ribose) polymerase‐mediated apoptosis in leukemia cells. However, the effects of MAC on autophagy in cancer cells and the underlying molecular mechanisms remain unknown. Here, we show that MAC induces autophagy in lung cancer cells. MAC significantly induced the expression of autophagy marker proteins including LC 3‐II, Beclin1, and ATG 7. MAC promoted AMP ‐activated protein kinase ( AMPK ) phosphorylation and inhibited the phosphorylation of mammalian target of rapamycin ( mTOR ) and its downstream signalling proteins P70S6K and 4 EBP 1. The AMPK activator AICAR upregulated LC 3‐II expression through the AMPK / mTOR pathway similar to the effects of MAC . MAC ‐induced LC 3‐II protein expression was slightly reduced in AMPK si RNA transfected cells. MAC upregulated hypoxia‐inducible factor‐1α ( HIF ‐1α) and BNIP 3, which are HIF ‐1α‐dependent autophagic proteins. Treatment with CoCl 2 , which mimics hypoxia, induced autophagy similar to the effect of MAC . The HIF ‐1α inhibitor YC ‐1 and HIF ‐1α si RNA inhibited the MAC ‐induced upregulation of LC 3‐II and BNIP 3. These results suggest that MAC induces autophagy via the AMPK / mTOR signalling pathway and by upregulating HIF ‐1α and BNIP 3 protein expression in lung cancer cells." @default.
• W2896909115 created "2018-10-26" @default.
• W2896909115 creator A5013171175 @default.
• W2896909115 creator A5034544453 @default.
• W2896909115 creator A5043272237 @default.
• W2896909115 creator A5074483970 @default.
• W2896909115 creator A5074949368 @default.
• W2896909115 creator A5091859347 @default.
• W2896909115 date "2018-10-19" @default.
• W2896909115 modified "2023-09-25" @default.
• W2896909115 title "Upregulation of AMPK by 4-O-methylascochlorin promotes autophagy via the HIF-1α expression" @default.
• W2896909115 cites W1546731875 @default.
• W2896909115 cites W1560977824 @default.
• W2896909115 cites W1562982734 @default.
• W2896909115 cites W1967413008 @default.
• W2896909115 cites W1970637701 @default.
• W2896909115 cites W1972553173 @default.
• W2896909115 cites W1994772532 @default.
• W2896909115 cites W1994823455 @default.
• W2896909115 cites W2014147259 @default.
• W2896909115 cites W2016243515 @default.
• W2896909115 cites W2020430280 @default.
• W2896909115 cites W2025364264 @default.
• W2896909115 cites W2026694952 @default.
• W2896909115 cites W2027566683 @default.
• W2896909115 cites W2029826833 @default.
• W2896909115 cites W2032491192 @default.
• W2896909115 cites W2039607936 @default.
• W2896909115 cites W2040100516 @default.
• W2896909115 cites W2050685477 @default.
• W2896909115 cites W2054889218 @default.
• W2896909115 cites W2057813271 @default.
• W2896909115 cites W2057921652 @default.
• W2896909115 cites W2059219172 @default.
• W2896909115 cites W2059729532 @default.
• W2896909115 cites W2069938223 @default.
• W2896909115 cites W2077499130 @default.
• W2896909115 cites W2079580613 @default.
• W2896909115 cites W2080100938 @default.
• W2896909115 cites W2091253690 @default.
• W2896909115 cites W2095386620 @default.
• W2896909115 cites W2100388369 @default.
• W2896909115 cites W2100942607 @default.
• W2896909115 cites W2103674704 @default.
• W2896909115 cites W2125302529 @default.
• W2896909115 cites W2129612050 @default.
• W2896909115 cites W2129687643 @default.
• W2896909115 cites W2129874885 @default.
• W2896909115 cites W2158535498 @default.
• W2896909115 cites W2158734599 @default.
• W2896909115 cites W2168104466 @default.
• W2896909115 cites W2310478501 @default.
• W2896909115 cites W2321277505 @default.
• W2896909115 cites W2416263718 @default.
• W2896909115 cites W2508534437 @default.
• W2896909115 cites W2512487767 @default.
• W2896909115 cites W66711298 @default.
• W2896909115 doi "https://doi.org/10.1111/jcmm.13933" @default.
• W2896909115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237564" @default.
• W2896909115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30338933" @default.
• W2896909115 hasPublicationYear "2018" @default.
• W2896909115 type Work @default.
• W2896909115 sameAs 2896909115 @default.
• W2896909115 citedByCount "15" @default.
• W2896909115 countsByYear W28969091152019 @default.
• W2896909115 countsByYear W28969091152020 @default.
• W2896909115 countsByYear W28969091152021 @default.
• W2896909115 countsByYear W28969091152022 @default.
• W2896909115 crossrefType "journal-article" @default.
• W2896909115 hasAuthorship W2896909115A5013171175 @default.
• W2896909115 hasAuthorship W2896909115A5034544453 @default.
• W2896909115 hasAuthorship W2896909115A5043272237 @default.
• W2896909115 hasAuthorship W2896909115A5074483970 @default.
• W2896909115 hasAuthorship W2896909115A5074949368 @default.
• W2896909115 hasAuthorship W2896909115A5091859347 @default.
• W2896909115 hasBestOaLocation W28969091151 @default.
• W2896909115 hasConcept C104317684 @default.
• W2896909115 hasConcept C11960822 @default.
• W2896909115 hasConcept C127561419 @default.
• W2896909115 hasConcept C153911025 @default.
• W2896909115 hasConcept C185592680 @default.
• W2896909115 hasConcept C190283241 @default.
• W2896909115 hasConcept C203522944 @default.
• W2896909115 hasConcept C22615655 @default.
• W2896909115 hasConcept C2776780712 @default.
• W2896909115 hasConcept C2780124434 @default.
• W2896909115 hasConcept C502942594 @default.
• W2896909115 hasConcept C54009773 @default.
• W2896909115 hasConcept C55493867 @default.
• W2896909115 hasConcept C62478195 @default.
• W2896909115 hasConcept C75217442 @default.
• W2896909115 hasConcept C86554907 @default.
• W2896909115 hasConcept C86803240 @default.
• W2896909115 hasConcept C95444343 @default.
• W2896909115 hasConcept C97029542 @default.
• W2896909115 hasConceptScore W2896909115C104317684 @default.
• W2896909115 hasConceptScore W2896909115C11960822 @default.
• W2896909115 hasConceptScore W2896909115C127561419 @default.

• next