Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896909997> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2896909997 endingPage "729" @default.
- W2896909997 startingPage "713" @default.
- W2896909997 abstract "A simple, efficient and atom-economic method has been developed for the synthesis of complex alkaloid-like compounds with spiro-fused indolo[2,1-b]quinazoline and cyclopropa[a]pyrrolizine or 3-azabicyclo[3.1.0]hexane moieties. We have found that one-pot, three-component 1,3-dipolar cycloaddition reactions allow the desired products to be obtained from various cyclopropene derivatives with tryptanthrin-derived azomethine ylides generated in situ, in good to high yields and excellent diastereoselectivity. The possibility of ylide generation was exemplified by using α-amino acids (l-proline, l-4-thiazolidincarboxylic acid) and simplest peptides (dipeptide Gly-Gly, tripeptide Gly-Gly-Gly). Quantum chemical investigations indicate that the reaction proceeds through the S-shaped azomethine ylide, the interaction of which with cyclopropenes proceeds via a less sterically hindered endo-transition state. The antitumor activity of some of spiro-tryptanthrin derivatives against erythroleukemia (K562), cervical carcinoma (HeLa) and colon carcinoma (CT26) cell lines was evaluated in vitro by MTS-assay." @default.
- W2896909997 created "2018-10-26" @default.
- W2896909997 creator A5001011772 @default.
- W2896909997 creator A5004079843 @default.
- W2896909997 creator A5028212152 @default.
- W2896909997 creator A5031282816 @default.
- W2896909997 creator A5049259288 @default.
- W2896909997 creator A5051376470 @default.
- W2896909997 creator A5054227986 @default.
- W2896909997 creator A5066107815 @default.
- W2896909997 creator A5068473235 @default.
- W2896909997 creator A5076580546 @default.
- W2896909997 creator A5091394638 @default.
- W2896909997 date "2018-10-10" @default.
- W2896909997 modified "2023-10-06" @default.
- W2896909997 title "Concise Synthesis of Tryptanthrin Spiro Analogues with In Vitro Antitumor Activity Based on One-Pot, Three-Component 1,3-Dipolar Cycloaddition of Azomethine Ylides to Сyclopropenes" @default.
- W2896909997 cites W1969765413 @default.
- W2896909997 cites W2010677658 @default.
- W2896909997 cites W2011146251 @default.
- W2896909997 cites W2022018899 @default.
- W2896909997 cites W2031223359 @default.
- W2896909997 cites W2034557548 @default.
- W2896909997 cites W2061734240 @default.
- W2896909997 cites W2062547618 @default.
- W2896909997 cites W2077468773 @default.
- W2896909997 cites W2112522430 @default.
- W2896909997 cites W2332754891 @default.
- W2896909997 cites W2566273184 @default.
- W2896909997 doi "https://doi.org/10.1055/s-0037-1611059" @default.
- W2896909997 hasPublicationYear "2018" @default.
- W2896909997 type Work @default.
- W2896909997 sameAs 2896909997 @default.
- W2896909997 citedByCount "25" @default.
- W2896909997 countsByYear W28969099972019 @default.
- W2896909997 countsByYear W28969099972020 @default.
- W2896909997 countsByYear W28969099972021 @default.
- W2896909997 countsByYear W28969099972022 @default.
- W2896909997 countsByYear W28969099972023 @default.
- W2896909997 crossrefType "journal-article" @default.
- W2896909997 hasAuthorship W2896909997A5001011772 @default.
- W2896909997 hasAuthorship W2896909997A5004079843 @default.
- W2896909997 hasAuthorship W2896909997A5028212152 @default.
- W2896909997 hasAuthorship W2896909997A5031282816 @default.
- W2896909997 hasAuthorship W2896909997A5049259288 @default.
- W2896909997 hasAuthorship W2896909997A5051376470 @default.
- W2896909997 hasAuthorship W2896909997A5054227986 @default.
- W2896909997 hasAuthorship W2896909997A5066107815 @default.
- W2896909997 hasAuthorship W2896909997A5068473235 @default.
- W2896909997 hasAuthorship W2896909997A5076580546 @default.
- W2896909997 hasAuthorship W2896909997A5091394638 @default.
- W2896909997 hasConcept C161790260 @default.
- W2896909997 hasConcept C178790620 @default.
- W2896909997 hasConcept C185592680 @default.
- W2896909997 hasConcept C202751555 @default.
- W2896909997 hasConcept C2777366897 @default.
- W2896909997 hasConcept C2777419590 @default.
- W2896909997 hasConcept C2779138802 @default.
- W2896909997 hasConcept C2779167645 @default.
- W2896909997 hasConcept C2779664164 @default.
- W2896909997 hasConcept C515207424 @default.
- W2896909997 hasConcept C55493867 @default.
- W2896909997 hasConcept C71240020 @default.
- W2896909997 hasConcept C88264902 @default.
- W2896909997 hasConceptScore W2896909997C161790260 @default.
- W2896909997 hasConceptScore W2896909997C178790620 @default.
- W2896909997 hasConceptScore W2896909997C185592680 @default.
- W2896909997 hasConceptScore W2896909997C202751555 @default.
- W2896909997 hasConceptScore W2896909997C2777366897 @default.
- W2896909997 hasConceptScore W2896909997C2777419590 @default.
- W2896909997 hasConceptScore W2896909997C2779138802 @default.
- W2896909997 hasConceptScore W2896909997C2779167645 @default.
- W2896909997 hasConceptScore W2896909997C2779664164 @default.
- W2896909997 hasConceptScore W2896909997C515207424 @default.
- W2896909997 hasConceptScore W2896909997C55493867 @default.
- W2896909997 hasConceptScore W2896909997C71240020 @default.
- W2896909997 hasConceptScore W2896909997C88264902 @default.
- W2896909997 hasFunder F4320324442 @default.
- W2896909997 hasIssue "03" @default.
- W2896909997 hasLocation W28969099971 @default.
- W2896909997 hasOpenAccess W2896909997 @default.
- W2896909997 hasPrimaryLocation W28969099971 @default.
- W2896909997 hasRelatedWork W1980133415 @default.
- W2896909997 hasRelatedWork W2047371035 @default.
- W2896909997 hasRelatedWork W2067924411 @default.
- W2896909997 hasRelatedWork W2071052162 @default.
- W2896909997 hasRelatedWork W2155806669 @default.
- W2896909997 hasRelatedWork W2896909997 @default.
- W2896909997 hasRelatedWork W2950065248 @default.
- W2896909997 hasRelatedWork W2950369383 @default.
- W2896909997 hasRelatedWork W4235799296 @default.
- W2896909997 hasRelatedWork W4237900237 @default.
- W2896909997 hasVolume "51" @default.
- W2896909997 isParatext "false" @default.
- W2896909997 isRetracted "false" @default.
- W2896909997 magId "2896909997" @default.
- W2896909997 workType "article" @default.