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• W2896911891 abstract "Disrupted functional connectivity has been highlighted as a common neural mechanism by which impaired cognitive function and mobility co-exist in older adults with mild cognitive impairment (MCI). However, few neuroimaging studies have investigated whether the co-manifestation of impaired cognitive function and mobility is associated with greater neural disruptions, than singular impairment (i.e. cognitive or mobility only). Understanding the extent of neural disruptions that coincide with clinical characteristics of patients may facilitate the development of effective screening strategies. This study compared functional connectivity of the default mode network (DMN), fronto-parietal network (FPN) and sensorimotor network (SMN) between 4 groups of older adults aged 65 years and older: 1) Healthy (no history of falls or MCI); 2) MCI (<26 Montreal Cognitive Assessment Score) without Falls; 3) Fallers (≥2 falls in past year) without MCI; and 4) Fallers with MCI. Functional MRI data was acquired at rest and during a simple motor task. During task, participants tapped in a specified pattern – from the index finger to pinky, and repeat – for 34 seconds. There was a significant interaction between MCI and Faller status for DMN-SMN connectivity (p=.004) during task. Post-hoc analyses revealed significantly greater DMN-SMN connectivity for Healthy vs Fallers without MCI (p=.01), and for Fallers with MCI vs Fallers without MCI (p=.001). Fallers without MCI had the lowest DMN-SMN connectivity (Fig 1), indicating they were able to deactivate the DMN during task. Conversely, Fallers with MCI had the greatest DMN-SMN connectivity, suggesting that they were unable to deactivate the DMN during task. Fig 1 shows the DMN-SMN connectivity increases from Fallers without MCI, to MCI without Falls, to Fallers with MCI. These data suggest: 1) the presence of MCI is more indicative of maladaptive DMN-SMN connectivity during task than Faller status; and 2) MCI with Falls is associated with a much greater level of disruptive DMN-SMN connectivity than either MCI or Faller status alone. Data from Healthy older adults suggest the motor task was not of sufficient challenge to require DMN deactivation. The combination of MCI and falls may be a significant risk profile for functional network disruptions. A bar graph presenting the mean functional connectivity between the default mode network (DMN) and sensorimotor network (SMN) between groups. Error bars represent the standard error; ∗ p≤.01." @default.
• W2896911891 created "2018-10-26" @default.
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• W2896911891 date "2018-07-01" @default.
• W2896911891 modified "2023-10-16" @default.
• W2896911891 title "P3‐432: HEAD OVER HEELS BUT I FORGET WHY: DISRUPTIVE FUNCTIONAL CONNECTIVITY IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT AND A HISTORY OF FALLS" @default.
• W2896911891 doi "https://doi.org/10.1016/j.jalz.2018.06.1795" @default.
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