FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896913289> ?p ?o ?g. }

• W2896913289 endingPage "197" @default.
• W2896913289 startingPage "192" @default.
• W2896913289 abstract "We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats. Furthermore, we evaluated the role of the serotonin (5-HT)2A receptor subtype in the anxiety-like behavior induced by such chemotherapy. Rats were intraperitoneally injected with doxorubicin and cyclophosphamide once a week for 2 weeks. This caused the rats to display anxiety-like behavior during the light-dark test. In addition, we examined the rats' 5-HT2A receptor-mediated behavioral responses. Combination treatment with doxorubicin and cyclophosphamide significantly increased (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (a 5-HT2A receptor agonist)-induced wet-dog shake activity. This anxiety-like behavior was significantly inhibited by mirtazapine, a 5-HT2A receptor antagonist/5-HT1A receptor agonist, and tandospirone, a partial 5-HT1A receptor agonist, but not by fluoxetine, a selective serotonin reuptake inhibitor. The anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment is mediated by hyperfunctioning of the 5-HT2A receptor. Thus, 5-HT2A receptor antagonists or 5-HT1A receptor agonists might be useful for treating chemotherapy-induced anxiety disorders." @default.
• W2896913289 created "2018-10-26" @default.
• W2896913289 creator A5004781096 @default.
• W2896913289 creator A5019076671 @default.
• W2896913289 creator A5021034663 @default.
• W2896913289 creator A5026597336 @default.
• W2896913289 creator A5033290048 @default.
• W2896913289 creator A5034349158 @default.
• W2896913289 creator A5050295898 @default.
• W2896913289 creator A5080139193 @default.
• W2896913289 creator A5087076909 @default.
• W2896913289 date "2018-11-01" @default.
• W2896913289 modified "2023-09-27" @default.
• W2896913289 title "Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats" @default.
• W2896913289 cites W1966065460 @default.
• W2896913289 cites W1977599131 @default.
• W2896913289 cites W1982036352 @default.
• W2896913289 cites W1987972424 @default.
• W2896913289 cites W1989498231 @default.
• W2896913289 cites W1990419595 @default.
• W2896913289 cites W1991552410 @default.
• W2896913289 cites W1994095895 @default.
• W2896913289 cites W1996327670 @default.
• W2896913289 cites W2002224654 @default.
• W2896913289 cites W2006864110 @default.
• W2896913289 cites W2009575820 @default.
• W2896913289 cites W2027728601 @default.
• W2896913289 cites W2057357882 @default.
• W2896913289 cites W2058396623 @default.
• W2896913289 cites W2075312309 @default.
• W2896913289 cites W2092986516 @default.
• W2896913289 cites W2095457080 @default.
• W2896913289 cites W2104516271 @default.
• W2896913289 cites W2105768061 @default.
• W2896913289 cites W2144665117 @default.
• W2896913289 cites W2148239264 @default.
• W2896913289 cites W2169824316 @default.
• W2896913289 cites W2302121233 @default.
• W2896913289 cites W2472032016 @default.
• W2896913289 cites W2569727330 @default.
• W2896913289 cites W606372334 @default.
• W2896913289 doi "https://doi.org/10.1016/j.jphs.2018.10.001" @default.
• W2896913289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30360947" @default.
• W2896913289 hasPublicationYear "2018" @default.
• W2896913289 type Work @default.
• W2896913289 sameAs 2896913289 @default.
• W2896913289 citedByCount "10" @default.
• W2896913289 countsByYear W28969132892019 @default.
• W2896913289 countsByYear W28969132892020 @default.
• W2896913289 countsByYear W28969132892021 @default.
• W2896913289 countsByYear W28969132892022 @default.
• W2896913289 crossrefType "journal-article" @default.
• W2896913289 hasAuthorship W2896913289A5004781096 @default.
• W2896913289 hasAuthorship W2896913289A5019076671 @default.
• W2896913289 hasAuthorship W2896913289A5021034663 @default.
• W2896913289 hasAuthorship W2896913289A5026597336 @default.
• W2896913289 hasAuthorship W2896913289A5033290048 @default.
• W2896913289 hasAuthorship W2896913289A5034349158 @default.
• W2896913289 hasAuthorship W2896913289A5050295898 @default.
• W2896913289 hasAuthorship W2896913289A5080139193 @default.
• W2896913289 hasAuthorship W2896913289A5087076909 @default.
• W2896913289 hasBestOaLocation W28969132891 @default.
• W2896913289 hasConcept C126322002 @default.
• W2896913289 hasConcept C134018914 @default.
• W2896913289 hasConcept C170493617 @default.
• W2896913289 hasConcept C185592680 @default.
• W2896913289 hasConcept C2775864247 @default.
• W2896913289 hasConcept C2776694085 @default.
• W2896913289 hasConcept C2776755627 @default.
• W2896913289 hasConcept C2776885963 @default.
• W2896913289 hasConcept C2778122271 @default.
• W2896913289 hasConcept C2778938600 @default.
• W2896913289 hasConcept C2781093953 @default.
• W2896913289 hasConcept C2781303535 @default.
• W2896913289 hasConcept C53910766 @default.
• W2896913289 hasConcept C58732023 @default.
• W2896913289 hasConcept C71924100 @default.
• W2896913289 hasConcept C98274493 @default.
• W2896913289 hasConceptScore W2896913289C126322002 @default.
• W2896913289 hasConceptScore W2896913289C134018914 @default.
• W2896913289 hasConceptScore W2896913289C170493617 @default.
• W2896913289 hasConceptScore W2896913289C185592680 @default.
• W2896913289 hasConceptScore W2896913289C2775864247 @default.
• W2896913289 hasConceptScore W2896913289C2776694085 @default.
• W2896913289 hasConceptScore W2896913289C2776755627 @default.
• W2896913289 hasConceptScore W2896913289C2776885963 @default.
• W2896913289 hasConceptScore W2896913289C2778122271 @default.
• W2896913289 hasConceptScore W2896913289C2778938600 @default.
• W2896913289 hasConceptScore W2896913289C2781093953 @default.
• W2896913289 hasConceptScore W2896913289C2781303535 @default.
• W2896913289 hasConceptScore W2896913289C53910766 @default.
• W2896913289 hasConceptScore W2896913289C58732023 @default.
• W2896913289 hasConceptScore W2896913289C71924100 @default.
• W2896913289 hasConceptScore W2896913289C98274493 @default.
• W2896913289 hasIssue "3" @default.
• W2896913289 hasLocation W28969132891 @default.
• W2896913289 hasLocation W28969132892 @default.
• W2896913289 hasOpenAccess W2896913289 @default.

• next