Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896918073> ?p ?o ?g. }
- W2896918073 endingPage "1800875" @default.
- W2896918073 startingPage "1800875" @default.
- W2896918073 abstract "The targeted and simultaneous delivery of diverse cargoes with vastly different properties by the same vehicle is highly appealing but challenging. Here, a bioactive nanocomposite hydrogel based on hyaluronic acid and self-assembled pamidronate-magnesium nanoparticles for the localized elution and on-demand simultaneous release of bioactive ions and small molecule drugs is described. The obtained nanocomposite hydrogels exhibit excellent injectability and efficient stress relaxation, thereby allowing easy injection and consequent adaptation of hydrogels to bone defects with irregular shapes. Magnesium ions released from the hydrogels promote osteogenic differentiation of the encapsulated human mesenchymal stem cells (hMSCs) and activation of alkaline phosphatase (ALP). The activated ALP subsequently catalyzes the dephosphorylation (activation) of Dex phosphate, a pro-drug of Dex, and expedites the release of Dex from hydrogels to further promote hMSC osteogenesis. This positive feedback circuit governing the activation and release of Dex significantly enhances bone regeneration at the hydrogel implantation sites. The findings suggest that these injectable nanocomposite hydrogels mediate optimized release of diverse therapeutic cargoes and effectively promote in situ bone regeneration via minimally invasive procedures." @default.
- W2896918073 created "2018-10-26" @default.
- W2896918073 creator A5001434487 @default.
- W2896918073 creator A5015289492 @default.
- W2896918073 creator A5017577614 @default.
- W2896918073 creator A5017895028 @default.
- W2896918073 creator A5025787180 @default.
- W2896918073 creator A5044061329 @default.
- W2896918073 creator A5050294834 @default.
- W2896918073 creator A5056721491 @default.
- W2896918073 creator A5058043561 @default.
- W2896918073 creator A5071703782 @default.
- W2896918073 creator A5083553643 @default.
- W2896918073 date "2018-10-22" @default.
- W2896918073 modified "2023-10-15" @default.
- W2896918073 title "Adaptable Hydrogels Mediate Cofactor-Assisted Activation of Biomarker-Responsive Drug Delivery via Positive Feedback for Enhanced Tissue Regeneration" @default.
- W2896918073 cites W129643616 @default.
- W2896918073 cites W1509760969 @default.
- W2896918073 cites W1537110470 @default.
- W2896918073 cites W1550830311 @default.
- W2896918073 cites W1745264954 @default.
- W2896918073 cites W1928995749 @default.
- W2896918073 cites W1943239370 @default.
- W2896918073 cites W1972488771 @default.
- W2896918073 cites W1977950302 @default.
- W2896918073 cites W1991642422 @default.
- W2896918073 cites W1993542424 @default.
- W2896918073 cites W1996720815 @default.
- W2896918073 cites W1997103341 @default.
- W2896918073 cites W2013980575 @default.
- W2896918073 cites W2014932842 @default.
- W2896918073 cites W2023649349 @default.
- W2896918073 cites W2031041031 @default.
- W2896918073 cites W2035087930 @default.
- W2896918073 cites W2050527365 @default.
- W2896918073 cites W2062447638 @default.
- W2896918073 cites W2066052326 @default.
- W2896918073 cites W2076189832 @default.
- W2896918073 cites W2081172951 @default.
- W2896918073 cites W2096735953 @default.
- W2896918073 cites W2144023435 @default.
- W2896918073 cites W2145305994 @default.
- W2896918073 cites W2160186897 @default.
- W2896918073 cites W2173114035 @default.
- W2896918073 cites W2257473733 @default.
- W2896918073 cites W2270498673 @default.
- W2896918073 cites W2323293084 @default.
- W2896918073 cites W2330090991 @default.
- W2896918073 cites W2347566208 @default.
- W2896918073 cites W2400899562 @default.
- W2896918073 cites W2410933689 @default.
- W2896918073 cites W2414272621 @default.
- W2896918073 cites W2510993966 @default.
- W2896918073 cites W2568455980 @default.
- W2896918073 cites W2610784388 @default.
- W2896918073 cites W2621576083 @default.
- W2896918073 cites W2741340736 @default.
- W2896918073 cites W2757584973 @default.
- W2896918073 cites W2769590605 @default.
- W2896918073 cites W2775556863 @default.
- W2896918073 cites W2781029745 @default.
- W2896918073 cites W2801458481 @default.
- W2896918073 cites W2803031642 @default.
- W2896918073 cites W2896918073 @default.
- W2896918073 cites W4250126132 @default.
- W2896918073 doi "https://doi.org/10.1002/advs.201800875" @default.
- W2896918073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299823" @default.
- W2896918073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30581701" @default.
- W2896918073 hasPublicationYear "2018" @default.
- W2896918073 type Work @default.
- W2896918073 sameAs 2896918073 @default.
- W2896918073 citedByCount "131" @default.
- W2896918073 countsByYear W28969180732019 @default.
- W2896918073 countsByYear W28969180732020 @default.
- W2896918073 countsByYear W28969180732021 @default.
- W2896918073 countsByYear W28969180732022 @default.
- W2896918073 countsByYear W28969180732023 @default.
- W2896918073 crossrefType "journal-article" @default.
- W2896918073 hasAuthorship W2896918073A5001434487 @default.
- W2896918073 hasAuthorship W2896918073A5015289492 @default.
- W2896918073 hasAuthorship W2896918073A5017577614 @default.
- W2896918073 hasAuthorship W2896918073A5017895028 @default.
- W2896918073 hasAuthorship W2896918073A5025787180 @default.
- W2896918073 hasAuthorship W2896918073A5044061329 @default.
- W2896918073 hasAuthorship W2896918073A5050294834 @default.
- W2896918073 hasAuthorship W2896918073A5056721491 @default.
- W2896918073 hasAuthorship W2896918073A5058043561 @default.
- W2896918073 hasAuthorship W2896918073A5071703782 @default.
- W2896918073 hasAuthorship W2896918073A5083553643 @default.
- W2896918073 hasBestOaLocation W28969180731 @default.
- W2896918073 hasConcept C105702510 @default.
- W2896918073 hasConcept C108586683 @default.
- W2896918073 hasConcept C12554922 @default.
- W2896918073 hasConcept C160160445 @default.
- W2896918073 hasConcept C171056886 @default.
- W2896918073 hasConcept C178666793 @default.
- W2896918073 hasConcept C178790620 @default.
- W2896918073 hasConcept C181199279 @default.