FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896918112> ?p ?o ?g. }

• W2896918112 abstract "Background: The hippocampus is an important limbic structure closely related to memory function. However, few studies have focused on the association between hippocampal subfields and age-related memory decline. We investigated the volume alterations of hippocampal subfields at different ages and assessed the correlations with Immediate and Delayed recall abilities. Materials and methods: A total of 275 participants aged 20-89 years were classified into 4 groups: Young, 20-35 years; Middle-early, 36-50 years; Middle-late, 51-65 years; Old, 66-89 years. All data were acquired from the Dallas Lifespan Brain Study (DLBS). The volumes of hippocampal subfields were obtained using Freesurfer software. Analysis of covariance (ANCOVA) was performed to analyze alterations of subfield volumes among the 4 groups, and multiple comparisons between groups were performed using the Bonferroni method. Spearman correlation with false discovery rate correction was used to investigate the relationship between memory recall scores and hippocampal subfield volumes. Results: Apart from no significant difference in the left parasubiculum (P = 0.269) and a slight difference in the right parasubiculum (P = 0.022), the volumes of other hippocampal subfields were significantly different across the adult lifespan (P < 0.001). The hippocampal fissure volume was increased in the Old group, while volumes for other subfields decreased. In addition, Immediate recall scores were associated with volumes of the bilateral molecular layer, granule cell layer of the dentate gyrus (GC-DG), cornus ammonis (CA) 1, CA2/3, CA4, left fimbria and hippocampal amygdala transition area (HATA), and right fissure (P < 0.05). Delayed recall scores were associated with the bilateral molecular layer, GC-DG, CA2/3 and CA4; left tail, presubiculum, CA1, subiculum, fimbria and HATA (P < 0.05). Conclusion: The parasubiculum volume was not significantly different across the adult lifespan, while atrophy in dementia patients in some studies. Based on these findings, we speculate that volume changes in this region might be considered as a biomarker for dementia disorders. Additionally, several hippocampal subfield volumes were significantly associated with memory scores, further highlighting the key role of the hippocampus in age-related memory decline. These regions could be used to assess the risk of memory decline across the adult lifespan." @default.
• W2896918112 created "2018-10-26" @default.
• W2896918112 creator A5002884286 @default.
• W2896918112 creator A5003138485 @default.
• W2896918112 creator A5003788807 @default.
• W2896918112 creator A5006964214 @default.
• W2896918112 creator A5016316795 @default.
• W2896918112 creator A5016422050 @default.
• W2896918112 creator A5025115516 @default.
• W2896918112 creator A5044144581 @default.
• W2896918112 creator A5044323235 @default.
• W2896918112 creator A5059445849 @default.
• W2896918112 creator A5059528020 @default.
• W2896918112 creator A5059540876 @default.
• W2896918112 creator A5066716873 @default.
• W2896918112 creator A5078774063 @default.
• W2896918112 creator A5082458281 @default.
• W2896918112 date "2018-10-10" @default.
• W2896918112 modified "2023-10-14" @default.
• W2896918112 title "The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan" @default.
• W2896918112 cites W1455747069 @default.
• W2896918112 cites W1543878663 @default.
• W2896918112 cites W1663551020 @default.
• W2896918112 cites W1907233035 @default.
• W2896918112 cites W1967005522 @default.
• W2896918112 cites W1975699010 @default.
• W2896918112 cites W1976922231 @default.
• W2896918112 cites W1984757600 @default.
• W2896918112 cites W2004293194 @default.
• W2896918112 cites W2017328363 @default.
• W2896918112 cites W2027015583 @default.
• W2896918112 cites W2030100345 @default.
• W2896918112 cites W2030545203 @default.
• W2896918112 cites W2031516169 @default.
• W2896918112 cites W2035284177 @default.
• W2896918112 cites W2040317796 @default.
• W2896918112 cites W2042512891 @default.
• W2896918112 cites W2047782284 @default.
• W2896918112 cites W2056313099 @default.
• W2896918112 cites W2058706194 @default.
• W2896918112 cites W2060139801 @default.
• W2896918112 cites W2063934960 @default.
• W2896918112 cites W2064345924 @default.
• W2896918112 cites W2067549362 @default.
• W2896918112 cites W2068777942 @default.
• W2896918112 cites W2069502544 @default.
• W2896918112 cites W2072630807 @default.
• W2896918112 cites W2072984221 @default.
• W2896918112 cites W2084443965 @default.
• W2896918112 cites W2084817972 @default.
• W2896918112 cites W2088269376 @default.
• W2896918112 cites W2089338935 @default.
• W2896918112 cites W2101480437 @default.
• W2896918112 cites W2102572922 @default.
• W2896918112 cites W2105086806 @default.
• W2896918112 cites W2105089471 @default.
• W2896918112 cites W2118784372 @default.
• W2896918112 cites W2129092558 @default.
• W2896918112 cites W2138258512 @default.
• W2896918112 cites W2143233814 @default.
• W2896918112 cites W2147326269 @default.
• W2896918112 cites W2148213577 @default.
• W2896918112 cites W2154763875 @default.
• W2896918112 cites W2155963684 @default.
• W2896918112 cites W2159574392 @default.
• W2896918112 cites W2162771276 @default.
• W2896918112 cites W2280881668 @default.
• W2896918112 cites W2287162579 @default.
• W2896918112 cites W2292533497 @default.
• W2896918112 cites W2301963636 @default.
• W2896918112 cites W2311393707 @default.
• W2896918112 cites W2412919983 @default.
• W2896918112 cites W2417433369 @default.
• W2896918112 cites W2487103609 @default.
• W2896918112 cites W2518662868 @default.
• W2896918112 cites W2552060604 @default.
• W2896918112 cites W2562554885 @default.
• W2896918112 cites W2567684291 @default.
• W2896918112 cites W2573011376 @default.
• W2896918112 cites W2592995462 @default.
• W2896918112 cites W2600856113 @default.
• W2896918112 cites W2605629718 @default.
• W2896918112 cites W2611096323 @default.
• W2896918112 cites W2742247374 @default.
• W2896918112 cites W2751745653 @default.
• W2896918112 cites W2782398719 @default.
• W2896918112 cites W2791814841 @default.
• W2896918112 cites W2800532458 @default.
• W2896918112 cites W2804353669 @default.
• W2896918112 cites W2806427269 @default.
• W2896918112 cites W2810160999 @default.
• W2896918112 cites W2950982591 @default.
• W2896918112 doi "https://doi.org/10.3389/fnagi.2018.00320" @default.
• W2896918112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6191512" @default.
• W2896918112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30364081" @default.
• W2896918112 hasPublicationYear "2018" @default.
• W2896918112 type Work @default.
• W2896918112 sameAs 2896918112 @default.
• W2896918112 citedByCount "59" @default.
• W2896918112 countsByYear W28969181122019 @default.

• next