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- W2896919125 abstract "目的探讨抗氧化剂α-苯基-N-叔丁基硝酮(PBN)对MPP+/MPTP诱发帕金森病模型的神经保护作用。 方法通过化学方法诱导自由基生成造成神经元损伤，分别在MPP+诱导损伤的细胞模型和MPTP诱导的动物模型中研究PBN的神经保护作用。 结果PBN对非细胞体系产生的自由基表现明显的清除作用，能明显抑制MPP+诱导的SH-SY5Y细胞内自由基生成，提高神经元的存活率。在MPTP诱导的小鼠帕金森病模型中，PBN能明显提高黑质致密部酪氨酸羟化酶阳性细胞数目，增加黑质致密部Nrf2和HO-1蛋白的表达，提高纹状体内DA及其代谢产物含量。 结论PBN对MPP+/MPTP诱发帕金森病模型具有良好的神经保护作用。" @default.
- W2896919125 created "2018-10-26" @default.
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- W2896919125 date "2018-07-25" @default.
- W2896919125 modified "2023-09-26" @default.
- W2896919125 title "α-苯基-N-叔丁基硝酮对MPP + /MPTP诱发帕金森病模型的神经保护作用" @default.
- W2896919125 doi "https://doi.org/10.3969/j.issn.1001-1978.2018.07.011" @default.
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