Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896925550> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2896925550 endingPage "e623" @default.
- W2896925550 startingPage "e623" @default.
- W2896925550 abstract "To review our institutional experience treating patients with node positive cervical cancer to assess whether RT dose was associated with pelvic lymph node control or GI toxicity. We retrospectively reviewed 390 patients with carcinoma of the uterine cervix treated with RT between October 1997 and October 2017. We included node positive patients and excluded those with <1 follow-up visit and those treated for palliative intent. Acute and late GI toxicity was recorded for all patients. A total of 77 patients with 206 lymph nodes were identified. Median stage at presentation was FIGO IIB. 13 patients were treated with definitive surgical resection followed by adjuvant radiation, of which 12 were treated to doses ≤50.4Gy. 64 patients were treated with definitive chemo-RT (CRT) of which 37 patients (57.8%) received ≤50.4Gy and 27 (42%) >50.4Gy. Patients treated definitively with pre-CRT LN ≥2cm had inferior pelvic LN control compared to patients with pre-CRT LN <2 cm (12 months, 88% vs 53%; p=0.05). While increased RT dose was not associated with pelvic LN control in patients with pre-RT lymph nodes measuring <2 cm (12 months, 88% vs 80%; p=0.53), RT dose was associated with pelvic lymph node control in patients with pre-RT pelvic LN ≥2 cm (12 months, 88% vs 31%; p=0.04). Acute grade 2 GI toxicity was not associated with RT dose (16% (n=46) vs 11% (n=4); p=0.88). 1 patient developed grade ≥2 late GI toxicity, treated to ≤50.4 Gy. Our experience treating patients with node positive cervical cancer supports the role of dose escalation for patients with regional LN ≥2cm. Higher pelvic LN dose is associated with improved regional control and does not seem to be associated with greater GI toxicity." @default.
- W2896925550 created "2018-10-26" @default.
- W2896925550 creator A5012560341 @default.
- W2896925550 creator A5014364226 @default.
- W2896925550 creator A5060568764 @default.
- W2896925550 creator A5067182017 @default.
- W2896925550 creator A5077778024 @default.
- W2896925550 date "2018-11-01" @default.
- W2896925550 modified "2023-09-26" @default.
- W2896925550 title "The Effects of Dose Escalation on Pelvic Lymph Node Control in Patients with Node Positive Cervical Cancer" @default.
- W2896925550 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1704" @default.
- W2896925550 hasPublicationYear "2018" @default.
- W2896925550 type Work @default.
- W2896925550 sameAs 2896925550 @default.
- W2896925550 citedByCount "1" @default.
- W2896925550 countsByYear W28969255502021 @default.
- W2896925550 crossrefType "journal-article" @default.
- W2896925550 hasAuthorship W2896925550A5012560341 @default.
- W2896925550 hasAuthorship W2896925550A5014364226 @default.
- W2896925550 hasAuthorship W2896925550A5060568764 @default.
- W2896925550 hasAuthorship W2896925550A5067182017 @default.
- W2896925550 hasAuthorship W2896925550A5077778024 @default.
- W2896925550 hasConcept C121608353 @default.
- W2896925550 hasConcept C126322002 @default.
- W2896925550 hasConcept C126894567 @default.
- W2896925550 hasConcept C141071460 @default.
- W2896925550 hasConcept C142724271 @default.
- W2896925550 hasConcept C146357865 @default.
- W2896925550 hasConcept C151730666 @default.
- W2896925550 hasConcept C2777740455 @default.
- W2896925550 hasConcept C2778220009 @default.
- W2896925550 hasConcept C2779720271 @default.
- W2896925550 hasConcept C2780849966 @default.
- W2896925550 hasConcept C29730261 @default.
- W2896925550 hasConcept C71924100 @default.
- W2896925550 hasConcept C86803240 @default.
- W2896925550 hasConceptScore W2896925550C121608353 @default.
- W2896925550 hasConceptScore W2896925550C126322002 @default.
- W2896925550 hasConceptScore W2896925550C126894567 @default.
- W2896925550 hasConceptScore W2896925550C141071460 @default.
- W2896925550 hasConceptScore W2896925550C142724271 @default.
- W2896925550 hasConceptScore W2896925550C146357865 @default.
- W2896925550 hasConceptScore W2896925550C151730666 @default.
- W2896925550 hasConceptScore W2896925550C2777740455 @default.
- W2896925550 hasConceptScore W2896925550C2778220009 @default.
- W2896925550 hasConceptScore W2896925550C2779720271 @default.
- W2896925550 hasConceptScore W2896925550C2780849966 @default.
- W2896925550 hasConceptScore W2896925550C29730261 @default.
- W2896925550 hasConceptScore W2896925550C71924100 @default.
- W2896925550 hasConceptScore W2896925550C86803240 @default.
- W2896925550 hasIssue "3" @default.
- W2896925550 hasLocation W28969255501 @default.
- W2896925550 hasOpenAccess W2896925550 @default.
- W2896925550 hasPrimaryLocation W28969255501 @default.
- W2896925550 hasRelatedWork W130771878 @default.
- W2896925550 hasRelatedWork W1855068278 @default.
- W2896925550 hasRelatedWork W1993781443 @default.
- W2896925550 hasRelatedWork W2024472469 @default.
- W2896925550 hasRelatedWork W2395525374 @default.
- W2896925550 hasRelatedWork W2435342977 @default.
- W2896925550 hasRelatedWork W2468856311 @default.
- W2896925550 hasRelatedWork W3029926684 @default.
- W2896925550 hasRelatedWork W3099598298 @default.
- W2896925550 hasRelatedWork W2621050524 @default.
- W2896925550 hasVolume "102" @default.
- W2896925550 isParatext "false" @default.
- W2896925550 isRetracted "false" @default.
- W2896925550 magId "2896925550" @default.
- W2896925550 workType "article" @default.