Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896927406> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2896927406 endingPage "21" @default.
- W2896927406 startingPage "11" @default.
- W2896927406 abstract "Movement of charges during enzyme catalytic cycle may be due to conformational changes, or to fast electron or proton transfer, or to both events. In each case, entropy production can be calculated using Terrel L. Hill's method, if relevant microscopic rate constants are known. When ranked by their evolutionary distance from putative common ancestor, three β-lactamases considered in this study show correspondingly increased catalytic constant, catalytic efficiency, and overall entropy production. The acylation and deacylation steps with concomitant proton shuttles are the most important contributors to overall entropy production. The maximal entropy production requirement for the ES↔EP or EP↔E + P step leads to optimal rate constants, performance parameters, and entropy production values, which are close to those extracted from experiments and also rank in accordance with evolutionary distances. Concurrent maximization of entropy productions for both proton transfer steps revealed that evolvability potential of different β-lactamases is similarly high. These results may have implications in particular for latent potential of β-lactamases to evolve further and in general for selection of optimized enzymes through natural or directed evolution." @default.
- W2896927406 created "2018-10-26" @default.
- W2896927406 creator A5022212584 @default.
- W2896927406 creator A5023460846 @default.
- W2896927406 creator A5049705658 @default.
- W2896927406 creator A5064750987 @default.
- W2896927406 creator A5068808729 @default.
- W2896927406 date "2019-01-01" @default.
- W2896927406 modified "2023-09-24" @default.
- W2896927406 title "The maximum entropy production requirement for proton transfers enhances catalytic efficiency for β-lactamases" @default.
- W2896927406 cites W1701997017 @default.
- W2896927406 cites W1861406683 @default.
- W2896927406 cites W1994593429 @default.
- W2896927406 cites W2000560592 @default.
- W2896927406 cites W2008892949 @default.
- W2896927406 cites W2011366098 @default.
- W2896927406 cites W2011513747 @default.
- W2896927406 cites W2022042432 @default.
- W2896927406 cites W2036642662 @default.
- W2896927406 cites W2037069499 @default.
- W2896927406 cites W2040573731 @default.
- W2896927406 cites W2071463329 @default.
- W2896927406 cites W2086138027 @default.
- W2896927406 cites W2091639850 @default.
- W2896927406 cites W2107025108 @default.
- W2896927406 cites W2119893119 @default.
- W2896927406 cites W2124019798 @default.
- W2896927406 cites W2130211116 @default.
- W2896927406 cites W2131824503 @default.
- W2896927406 cites W2140959622 @default.
- W2896927406 cites W2293953879 @default.
- W2896927406 cites W2311203695 @default.
- W2896927406 cites W2313735092 @default.
- W2896927406 cites W2380593613 @default.
- W2896927406 cites W2519539312 @default.
- W2896927406 cites W2562450823 @default.
- W2896927406 cites W2761766018 @default.
- W2896927406 cites W2781781451 @default.
- W2896927406 cites W2884903803 @default.
- W2896927406 doi "https://doi.org/10.1016/j.bpc.2018.10.004" @default.
- W2896927406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30448627" @default.
- W2896927406 hasPublicationYear "2019" @default.
- W2896927406 type Work @default.
- W2896927406 sameAs 2896927406 @default.
- W2896927406 citedByCount "4" @default.
- W2896927406 countsByYear W28969274062019 @default.
- W2896927406 countsByYear W28969274062021 @default.
- W2896927406 countsByYear W28969274062023 @default.
- W2896927406 crossrefType "journal-article" @default.
- W2896927406 hasAuthorship W2896927406A5022212584 @default.
- W2896927406 hasAuthorship W2896927406A5023460846 @default.
- W2896927406 hasAuthorship W2896927406A5049705658 @default.
- W2896927406 hasAuthorship W2896927406A5064750987 @default.
- W2896927406 hasAuthorship W2896927406A5068808729 @default.
- W2896927406 hasConcept C106301342 @default.
- W2896927406 hasConcept C121332964 @default.
- W2896927406 hasConcept C161790260 @default.
- W2896927406 hasConcept C185592680 @default.
- W2896927406 hasConcept C207282930 @default.
- W2896927406 hasConcept C55493867 @default.
- W2896927406 hasConcept C97355855 @default.
- W2896927406 hasConceptScore W2896927406C106301342 @default.
- W2896927406 hasConceptScore W2896927406C121332964 @default.
- W2896927406 hasConceptScore W2896927406C161790260 @default.
- W2896927406 hasConceptScore W2896927406C185592680 @default.
- W2896927406 hasConceptScore W2896927406C207282930 @default.
- W2896927406 hasConceptScore W2896927406C55493867 @default.
- W2896927406 hasConceptScore W2896927406C97355855 @default.
- W2896927406 hasFunder F4320322554 @default.
- W2896927406 hasLocation W28969274061 @default.
- W2896927406 hasLocation W28969274062 @default.
- W2896927406 hasOpenAccess W2896927406 @default.
- W2896927406 hasPrimaryLocation W28969274061 @default.
- W2896927406 hasRelatedWork W1967272142 @default.
- W2896927406 hasRelatedWork W1977526960 @default.
- W2896927406 hasRelatedWork W1985022030 @default.
- W2896927406 hasRelatedWork W1990271477 @default.
- W2896927406 hasRelatedWork W2016332830 @default.
- W2896927406 hasRelatedWork W2037111427 @default.
- W2896927406 hasRelatedWork W2054858797 @default.
- W2896927406 hasRelatedWork W2054915042 @default.
- W2896927406 hasRelatedWork W2554957841 @default.
- W2896927406 hasRelatedWork W3092112701 @default.
- W2896927406 hasVolume "244" @default.
- W2896927406 isParatext "false" @default.
- W2896927406 isRetracted "false" @default.
- W2896927406 magId "2896927406" @default.
- W2896927406 workType "article" @default.