Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896930416> ?p ?o ?g. }
- W2896930416 endingPage "677" @default.
- W2896930416 startingPage "665" @default.
- W2896930416 abstract "Alzheimer's disease (AD) is an age-related neurodegenerative disorder that accounts for numerous deaths worldwide. AD is the most common cause of dementia, characterized by accumulation of fibrous amyloid beta protein in the brain with clinical symptoms, such as loss of intellectual and social skills, gradually leading to the death of brain cells. The genetic complexity of AD during disease progression requires a systems-level understanding to design viable therapeutics. We present an integrative computational analysis to prioritize AD-associated genes outlined through a protein–protein interaction network. Multiple topological parameters of the network were considered to target proteins which are accountable for disease susceptibility. Furthermore, in silico protein structure modeling and molecular dynamics simulation approaches were implemented to characterize presenilin 2 (PSEN2) protein as one of the leading targets in the network. The findings are constructive to aid future drug discovery endeavors in the treatment of AD." @default.
- W2896930416 created "2018-10-26" @default.
- W2896930416 creator A5059797786 @default.
- W2896930416 creator A5060438749 @default.
- W2896930416 creator A5083143424 @default.
- W2896930416 date "2018-10-01" @default.
- W2896930416 modified "2023-10-06" @default.
- W2896930416 title "Drug Target Prioritization for Alzheimer's Disease Using Protein Interaction Network Analysis" @default.
- W2896930416 cites W1510774549 @default.
- W2896930416 cites W1517622624 @default.
- W2896930416 cites W1797408175 @default.
- W2896930416 cites W1890431460 @default.
- W2896930416 cites W1966841369 @default.
- W2896930416 cites W1969875677 @default.
- W2896930416 cites W1981021420 @default.
- W2896930416 cites W1984614832 @default.
- W2896930416 cites W1986191025 @default.
- W2896930416 cites W1994803330 @default.
- W2896930416 cites W1999265216 @default.
- W2896930416 cites W2009019945 @default.
- W2896930416 cites W2015642465 @default.
- W2896930416 cites W2017498808 @default.
- W2896930416 cites W2018518196 @default.
- W2896930416 cites W2018934112 @default.
- W2896930416 cites W2020230298 @default.
- W2896930416 cites W2020300726 @default.
- W2896930416 cites W2021723654 @default.
- W2896930416 cites W2029162992 @default.
- W2896930416 cites W2029667189 @default.
- W2896930416 cites W2031869443 @default.
- W2896930416 cites W2033354781 @default.
- W2896930416 cites W2035058961 @default.
- W2896930416 cites W2035266068 @default.
- W2896930416 cites W2041352318 @default.
- W2896930416 cites W2045153164 @default.
- W2896930416 cites W2046209489 @default.
- W2896930416 cites W2046784267 @default.
- W2896930416 cites W2047998870 @default.
- W2896930416 cites W2051381895 @default.
- W2896930416 cites W2051434435 @default.
- W2896930416 cites W2053039860 @default.
- W2896930416 cites W2055655674 @default.
- W2896930416 cites W2055776806 @default.
- W2896930416 cites W2058723245 @default.
- W2896930416 cites W2065996976 @default.
- W2896930416 cites W2066049444 @default.
- W2896930416 cites W2067200099 @default.
- W2896930416 cites W2067305633 @default.
- W2896930416 cites W2070711680 @default.
- W2896930416 cites W2072034250 @default.
- W2896930416 cites W2073738984 @default.
- W2896930416 cites W2079531196 @default.
- W2896930416 cites W2080509092 @default.
- W2896930416 cites W2081375228 @default.
- W2896930416 cites W2083633251 @default.
- W2896930416 cites W2088858515 @default.
- W2896930416 cites W2092661111 @default.
- W2896930416 cites W2095135236 @default.
- W2896930416 cites W2096173332 @default.
- W2896930416 cites W2099571503 @default.
- W2896930416 cites W2102993309 @default.
- W2896930416 cites W2105752911 @default.
- W2896930416 cites W2106083328 @default.
- W2896930416 cites W2106278308 @default.
- W2896930416 cites W2108292688 @default.
- W2896930416 cites W2114133572 @default.
- W2896930416 cites W2124236304 @default.
- W2896930416 cites W2125722904 @default.
- W2896930416 cites W2134845483 @default.
- W2896930416 cites W2136902554 @default.
- W2896930416 cites W2148911143 @default.
- W2896930416 cites W2159675211 @default.
- W2896930416 cites W2165589151 @default.
- W2896930416 cites W2166625407 @default.
- W2896930416 cites W2178350640 @default.
- W2896930416 cites W2183091920 @default.
- W2896930416 cites W2202954603 @default.
- W2896930416 cites W2290572640 @default.
- W2896930416 cites W2294516783 @default.
- W2896930416 cites W2444226747 @default.
- W2896930416 cites W2533881064 @default.
- W2896930416 cites W2559028527 @default.
- W2896930416 cites W2623587811 @default.
- W2896930416 cites W2915536738 @default.
- W2896930416 cites W4211156109 @default.
- W2896930416 doi "https://doi.org/10.1089/omi.2018.0131" @default.
- W2896930416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30346884" @default.
- W2896930416 hasPublicationYear "2018" @default.
- W2896930416 type Work @default.
- W2896930416 sameAs 2896930416 @default.
- W2896930416 citedByCount "5" @default.
- W2896930416 countsByYear W28969304162020 @default.
- W2896930416 countsByYear W28969304162022 @default.
- W2896930416 countsByYear W28969304162023 @default.
- W2896930416 crossrefType "journal-article" @default.
- W2896930416 hasAuthorship W2896930416A5059797786 @default.
- W2896930416 hasAuthorship W2896930416A5060438749 @default.
- W2896930416 hasAuthorship W2896930416A5083143424 @default.