FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896930458> ?p ?o ?g. }

• W2896930458 endingPage "9" @default.
• W2896930458 startingPage "1" @default.
• W2896930458 abstract "Bj-PRO-7a and Bj-PRO-10c belong to a family of proline-rich oligopeptides (PROs) identified in Bothrops jararaca (Bj) crude venom. Previous studies have shown an antihypertensive effect evoked by theses peptides. However, the mechanisms underlying the direct effects on vessels and heart remain to be unraveled. Thus, we investigated the effect of the Bj-PRO-7a and Bj-PRO-10c in the aorta and coronary arteries and in cardiac contractility in normotensive (Wistar) and hypertensive (SHR) rats. Pre-constricted aortic rings were exposed to increasing concentrations of Bj-PROs in presence or absence of muscarinic type 1 receptor antagonist (Pirenzepine), nonselective muscarinic receptor antagonist (Atropine), nitric oxide synthase inhibitor (L-NAME), guanylyl cyclase inhibitor (ODQ), adenylyl cyclase inhibitor (MDL), or argininosuccinate synthetase inhibitor (MDLA). The effects of Bj-PROs in the cardiac contractility and coronary vasomotricity were evaluated using Langendorff perfused heart preparation. The rat hearts were perfused with Bj-PRO-7a or Bj-PRO-10c in absence or presence of L-NAME, ODQ or MDL. Both Bj-PROs induced endothelium-dependent vasorelaxation in aortic rings from Wistars and SHRs. These effects were inhibited by L-NAME, ODQ or MDL. Atropine and Pirenzepine blocked the vasorelaxant effect of Bj-PRO-7a in aorta from both strains. MDLA inhibited the Bj-PRO-10c-induced vasorelaxation in aortic rings from SHR, but not Wistar. The Bj-PRO-7a induced coronary vasodilation only in SHR. L-NAME, ODQ and MDL inhibited this effect. Bj-PRO-10c induced coronary vasodilatation in both strains, which was blocked by L-NAME, ODQ and MDL. Bj-PRO-7a decreased the dP/dt max in Wistar hearts and the dP/dt min in Wistar and SHR hearts. These effects were abolished by L-NAME. Bj-PRO-10c decreased dP/dt max and dP/dt min in hearts from normotensive and hypertensive animals, which were abolished in the presence of L-NAME, MDL and ODQ. In summary, the Bj-PROs induced endothelium-dependent vasorelaxation in rat thoracic aorta, coronary vasodilation and negative inotropic effects through mechanisms mediated by activation of nitric oxide pathway." @default.
• W2896930458 created "2018-10-26" @default.
• W2896930458 creator A5027102675 @default.
• W2896930458 creator A5028688300 @default.
• W2896930458 creator A5052909958 @default.
• W2896930458 creator A5061117911 @default.
• W2896930458 creator A5066420427 @default.
• W2896930458 date "2018-12-01" @default.
• W2896930458 modified "2023-10-17" @default.
• W2896930458 title "BJ-PRO-7A and BJ-PRO-10C induce vasodilatation and inotropic effects in normotensive and hypertensive rats: Role of nitric oxide and muscarinic receptors" @default.
• W2896930458 cites W1897133249 @default.
• W2896930458 cites W1966615064 @default.
• W2896930458 cites W1967431809 @default.
• W2896930458 cites W1978545009 @default.
• W2896930458 cites W1984280612 @default.
• W2896930458 cites W1986470223 @default.
• W2896930458 cites W1991074939 @default.
• W2896930458 cites W1991333067 @default.
• W2896930458 cites W1997379621 @default.
• W2896930458 cites W2009899857 @default.
• W2896930458 cites W2013427200 @default.
• W2896930458 cites W2017565733 @default.
• W2896930458 cites W2026975863 @default.
• W2896930458 cites W2029101242 @default.
• W2896930458 cites W2029954557 @default.
• W2896930458 cites W2038108794 @default.
• W2896930458 cites W2043125642 @default.
• W2896930458 cites W2043421724 @default.
• W2896930458 cites W2044031646 @default.
• W2896930458 cites W2048782251 @default.
• W2896930458 cites W2051433308 @default.
• W2896930458 cites W2054543809 @default.
• W2896930458 cites W2055622424 @default.
• W2896930458 cites W2059808228 @default.
• W2896930458 cites W2067763402 @default.
• W2896930458 cites W2076160946 @default.
• W2896930458 cites W2077969074 @default.
• W2896930458 cites W2079767918 @default.
• W2896930458 cites W2082153473 @default.
• W2896930458 cites W2082538783 @default.
• W2896930458 cites W2106707681 @default.
• W2896930458 cites W2107691211 @default.
• W2896930458 cites W2113589294 @default.
• W2896930458 cites W2114664338 @default.
• W2896930458 cites W2120670639 @default.
• W2896930458 cites W2122326747 @default.
• W2896930458 cites W2125519662 @default.
• W2896930458 cites W2127861404 @default.
• W2896930458 cites W2136191791 @default.
• W2896930458 cites W2143914955 @default.
• W2896930458 cites W2144001627 @default.
• W2896930458 cites W2155092400 @default.
• W2896930458 cites W2157701601 @default.
• W2896930458 cites W2161563348 @default.
• W2896930458 cites W2318393308 @default.
• W2896930458 cites W2322718002 @default.
• W2896930458 cites W2414561396 @default.
• W2896930458 cites W2519708586 @default.
• W2896930458 cites W4245437819 @default.
• W2896930458 doi "https://doi.org/10.1016/j.peptides.2018.10.005" @default.
• W2896930458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30355532" @default.
• W2896930458 hasPublicationYear "2018" @default.
• W2896930458 type Work @default.
• W2896930458 sameAs 2896930458 @default.
• W2896930458 citedByCount "2" @default.
• W2896930458 countsByYear W28969304582021 @default.
• W2896930458 countsByYear W28969304582022 @default.
• W2896930458 crossrefType "journal-article" @default.
• W2896930458 hasAuthorship W2896930458A5027102675 @default.
• W2896930458 hasAuthorship W2896930458A5028688300 @default.
• W2896930458 hasAuthorship W2896930458A5052909958 @default.
• W2896930458 hasAuthorship W2896930458A5061117911 @default.
• W2896930458 hasAuthorship W2896930458A5066420427 @default.
• W2896930458 hasConcept C120770815 @default.
• W2896930458 hasConcept C126322002 @default.
• W2896930458 hasConcept C134018914 @default.
• W2896930458 hasConcept C170493617 @default.
• W2896930458 hasConcept C173803235 @default.
• W2896930458 hasConcept C185592680 @default.
• W2896930458 hasConcept C2775859210 @default.
• W2896930458 hasConcept C2778616617 @default.
• W2896930458 hasConcept C2778827303 @default.
• W2896930458 hasConcept C33789571 @default.
• W2896930458 hasConcept C39133596 @default.
• W2896930458 hasConcept C519581460 @default.
• W2896930458 hasConcept C71924100 @default.
• W2896930458 hasConcept C98274493 @default.
• W2896930458 hasConceptScore W2896930458C120770815 @default.
• W2896930458 hasConceptScore W2896930458C126322002 @default.
• W2896930458 hasConceptScore W2896930458C134018914 @default.
• W2896930458 hasConceptScore W2896930458C170493617 @default.
• W2896930458 hasConceptScore W2896930458C173803235 @default.
• W2896930458 hasConceptScore W2896930458C185592680 @default.
• W2896930458 hasConceptScore W2896930458C2775859210 @default.
• W2896930458 hasConceptScore W2896930458C2778616617 @default.
• W2896930458 hasConceptScore W2896930458C2778827303 @default.
• W2896930458 hasConceptScore W2896930458C33789571 @default.
• W2896930458 hasConceptScore W2896930458C39133596 @default.

• next