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• W2896931383 endingPage "1233" @default.
• W2896931383 startingPage "1224" @default.
• W2896931383 abstract "The circumsporozoite protein (CSP) is the major surface protein of malaria sporozoites (SPZs), the motile and invasive parasite stage inoculated in the host skin by infected mosquitoes. Antibodies against the central CSP repeats of different plasmodial species are known to block SPZ infectivity1-5, but the precise mechanism by which these effectors operate is not completely understood. Here, using a rodent Plasmodium yoelii malaria model, we show that sterile protection mediated by anti-P. yoelii CSP humoral immunity depends on the parasite inoculation into the host skin, where antibodies inhibit motility and kill P. yoelii SPZs via a characteristic 'dotty death' phenotype. Passive transfer of an anti-repeat monoclonal antibody (mAb) recapitulates the skin inoculation-dependent protection, in a complement- and Fc receptor γ-independent manner. This purified mAb also decreases motility and, notably, induces the dotty death of P. yoelii SPZs in vitro. Cytotoxicity is species-transcendent since cognate anti-CSP repeat mAbs also kill Plasmodium berghei and Plasmodium falciparum SPZs. mAb cytotoxicity requires the actomyosin motor-dependent translocation and stripping of the protective CSP surface coat, rendering the parasite membrane susceptible to the SPZ pore-forming-like protein secreted to wound and traverse the host cell membrane6. The loss of SPZ fitness caused by anti-P. yoelii CSP repeat antibodies is thus a dynamic process initiated in the host skin where SPZs either stop moving7, or migrate and traverse cells to progress through the host tissues7-9 at the eventual expense of their own life." @default.
• W2896931383 created "2018-10-26" @default.
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• W2896931383 date "2018-10-22" @default.
• W2896931383 modified "2023-10-16" @default.
• W2896931383 title "Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin" @default.
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• W2896931383 doi "https://doi.org/10.1038/s41564-018-0254-z" @default.
• W2896931383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30349082" @default.
• W2896931383 hasPublicationYear "2018" @default.
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