Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896933546> ?p ?o ?g. }
- W2896933546 abstract "The dimerization of 70S ribosomes (100S complex) plays an important role in translational regulation and infectivity of the major human pathogen Staphylococcus aureus . Although the dimerizing factor HPF has been characterized biochemically, the pathways that regulate 100S ribosome abundance remain elusive. We identified a metabolite- and nutrient-sensing transcription factor, CodY, that serves both as an activator and a repressor of hpf expression in nutrient- and temperature-dependent manners. Furthermore, CodY-mediated activation of hpf masks a secondary hpf transcript derived from a general stress response SigB promoter. CodY and SigB regulate a repertoire of virulence genes. The unexpected link between ribosome homeostasis and the two master virulence regulators provides new opportunities for alternative druggable sites." @default.
- W2896933546 created "2018-10-26" @default.
- W2896933546 creator A5018685454 @default.
- W2896933546 creator A5029815230 @default.
- W2896933546 creator A5064594498 @default.
- W2896933546 creator A5074581391 @default.
- W2896933546 creator A5084216853 @default.
- W2896933546 date "2018-12-15" @default.
- W2896933546 modified "2023-10-12" @default.
- W2896933546 title "Thermal and Nutritional Regulation of Ribosome Hibernation in Staphylococcus aureus" @default.
- W2896933546 cites W1500152947 @default.
- W2896933546 cites W1516043067 @default.
- W2896933546 cites W1601428669 @default.
- W2896933546 cites W1603453073 @default.
- W2896933546 cites W1733886482 @default.
- W2896933546 cites W1862273946 @default.
- W2896933546 cites W1899647260 @default.
- W2896933546 cites W1901538753 @default.
- W2896933546 cites W1907520509 @default.
- W2896933546 cites W1939080849 @default.
- W2896933546 cites W1963566555 @default.
- W2896933546 cites W1963928439 @default.
- W2896933546 cites W1974544574 @default.
- W2896933546 cites W1975379404 @default.
- W2896933546 cites W1982777646 @default.
- W2896933546 cites W1989450256 @default.
- W2896933546 cites W1993874265 @default.
- W2896933546 cites W1996298113 @default.
- W2896933546 cites W1997640812 @default.
- W2896933546 cites W1998125347 @default.
- W2896933546 cites W2005685856 @default.
- W2896933546 cites W2006840128 @default.
- W2896933546 cites W2007724300 @default.
- W2896933546 cites W2008380444 @default.
- W2896933546 cites W2014633956 @default.
- W2896933546 cites W2017140888 @default.
- W2896933546 cites W2024837019 @default.
- W2896933546 cites W2034895168 @default.
- W2896933546 cites W2045915531 @default.
- W2896933546 cites W2046708334 @default.
- W2896933546 cites W2053604896 @default.
- W2896933546 cites W2054006412 @default.
- W2896933546 cites W2057427059 @default.
- W2896933546 cites W2059693313 @default.
- W2896933546 cites W2062221023 @default.
- W2896933546 cites W2067148638 @default.
- W2896933546 cites W2067252347 @default.
- W2896933546 cites W2069549031 @default.
- W2896933546 cites W2073354904 @default.
- W2896933546 cites W2086287990 @default.
- W2896933546 cites W2094898751 @default.
- W2896933546 cites W2097360713 @default.
- W2896933546 cites W2107277218 @default.
- W2896933546 cites W2114286698 @default.
- W2896933546 cites W2115097685 @default.
- W2896933546 cites W2125957234 @default.
- W2896933546 cites W2127113854 @default.
- W2896933546 cites W2143527951 @default.
- W2896933546 cites W2145402589 @default.
- W2896933546 cites W2147524566 @default.
- W2896933546 cites W2147674484 @default.
- W2896933546 cites W2152819297 @default.
- W2896933546 cites W2155568318 @default.
- W2896933546 cites W2156845325 @default.
- W2896933546 cites W2159713856 @default.
- W2896933546 cites W2162217391 @default.
- W2896933546 cites W2165035045 @default.
- W2896933546 cites W2222258085 @default.
- W2896933546 cites W2226150319 @default.
- W2896933546 cites W2277319443 @default.
- W2896933546 cites W2322506796 @default.
- W2896933546 cites W2322749552 @default.
- W2896933546 cites W2343580886 @default.
- W2896933546 cites W2397584302 @default.
- W2896933546 cites W2419335772 @default.
- W2896933546 cites W2489579440 @default.
- W2896933546 cites W2511373692 @default.
- W2896933546 cites W2521759960 @default.
- W2896933546 cites W2531355008 @default.
- W2896933546 cites W2562045321 @default.
- W2896933546 cites W2563408447 @default.
- W2896933546 cites W2593419960 @default.
- W2896933546 cites W2607285114 @default.
- W2896933546 cites W2611906432 @default.
- W2896933546 cites W2683537437 @default.
- W2896933546 cites W2751895478 @default.
- W2896933546 cites W2755679890 @default.
- W2896933546 cites W2758840733 @default.
- W2896933546 cites W2759476086 @default.
- W2896933546 cites W2770806876 @default.
- W2896933546 cites W2773024994 @default.
- W2896933546 cites W2784783226 @default.
- W2896933546 cites W2795298397 @default.
- W2896933546 cites W2799400602 @default.
- W2896933546 cites W2805729328 @default.
- W2896933546 cites W2887128430 @default.
- W2896933546 cites W290865292 @default.
- W2896933546 cites W1964184380 @default.
- W2896933546 doi "https://doi.org/10.1128/jb.00426-18" @default.
- W2896933546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6256015" @default.