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• W2896934530 abstract "Radiotherapy (RT) plays a crucial role in the treatment of cervical carcinoma which is one of the most common cancers diagnosed in women worldwide. Unfortunately, nearly 50 % of all patients with cervical carcinoma do not respond to standard treatment due to tumor radioresistance. Acquired radioresistance during RT has been considered as one of the most important reasons for local tumor recurrence or treatment failure. Although its genetic background is thoroughly investigated, rather little is known about the role of small non-coding RNAs (sncRNA) in cervical carcinoma. tRNA-derived RNA fragments (tRFs) represent a new class of sncRNAs, which are present in a broad range of species and have been reported to involve in various biological processes. The aim of the present study was to investigate the possible role of tRFs in the acquisition of radioresistance in cervical squamous cell carcinoma (SCC). Total RNA was isolated from human parental cervical SCC cell line SiHa and self-established radioresistant cell line SiHa-R, and processed for RNA sequencing and tRFs expression analysis. Quantitative real-time PCR (qPCR) was used to confirm the tRFs expression profiles obtained from the sequencing data. The expression levels of tRFs selected for validation by qPCR were detected in a cohort of clinical samples of tumor tissue and serum from cervical SCC patients with different radiotherapy sensitivity. The human radioresistant cervical SCC cell line SiHa-R has been established by gradient dose irradiation treatment. Among the detected candidate 2207 tRFs genes, significant upregulation of 40 tRFs and downregulation of 35 tRFs in radioresistant cervical SCC cell line SiHa-R were observed compared with the parental cell line SiHa (fold change ≥ 2.0 and P < 0.05). There were 10 out of these candidate tRFs were validated by real-time PCR. It showed that tRF-16-JUO9YED was significantly upregulated in patients with cervical SCC who did not respond to RT. Our study revealed a comprehensive expression and functional profile of differentially expressed tRFs in radioresistant cervical SCC cells, indicating possible involvement of these dysregulated tRFs in the regulation of the process of radioresistance. Additionally, we showed that overexpression of tRF-16-JUO9YED could be used as a radioresistance biomarker in patients with cervical SCC." @default.
• W2896934530 created "2018-10-26" @default.
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• W2896934530 date "2018-11-01" @default.
• W2896934530 modified "2023-09-27" @default.
• W2896934530 title "Preliminary Investigation of Differential tRNA-Derived RNA Fragments Expression Profiling and Biological Role in Radioresistant Cervical Squamous Cell Carcinoma" @default.
• W2896934530 doi "https://doi.org/10.1016/j.ijrobp.2018.07.658" @default.
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