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- W2896935109 abstract "Microglia regulate synaptic circuit remodeling and phagocytose synaptic material in the healthy brain; however, the mechanisms directing microglia to engulf specific synapses and avoid others remain unknown. Here, we demonstrate that an innate immune signaling pathway protects synapses from inappropriate removal. The expression patterns of CD47 and its receptor, SIRPα, correlated with peak pruning in the developing retinogeniculate system, and mice lacking these proteins exhibited increased microglial engulfment of retinogeniculate inputs and reduced synapse numbers in the dorsal lateral geniculate nucleus. CD47-deficient mice also displayed increased functional pruning, as measured by electrophysiology. In addition, CD47 was found to be required for neuronal activity-mediated changes in engulfment, as microglia in CD47 knockout mice failed to display preferential engulfment of less active inputs. Taken together, these results demonstrate that CD47-SIRPα signaling prevents excess microglial phagocytosis and show that molecular brakes can be regulated by activity to protect specific inputs." @default.
- W2896935109 created "2018-10-26" @default.
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- W2896935109 date "2018-10-01" @default.
- W2896935109 modified "2023-10-16" @default.
- W2896935109 title "CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development" @default.
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- W2896935109 doi "https://doi.org/10.1016/j.neuron.2018.09.017" @default.
- W2896935109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6314207" @default.
- W2896935109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30308165" @default.
- W2896935109 hasPublicationYear "2018" @default.
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