FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896935255> ?p ?o ?g. }

• W2896935255 abstract "Several broadly neutralizing antibodies (bNAbs) that can target HIV strains with large degrees of variability have recently been identified. However, efforts to induce synthesis of such bNAbs that can protect against HIV infection have not met with much success. Identification of specific epitopes encoded in the HIV-1 envelope (Env) that can direct the host to synthesize bNAbs remains a challenge. In a previous study, we identified 12 antiretroviral therapy-naive HIV-1-infected individuals whose plasma exhibited broad cross-clade neutralization property against different clades of HIV-1. In this study, we sequenced the full-length HIV-1 gp160 from 11 of these individuals and analyzed the sequences to identify bNAb epitopes. We identified critical residues in the viral envelopes that contribute to the formation of conformational epitopes and possibly induce the production of bNAbs, using in silico methods. We found that many of the sequences had conserved glycans at positions N160 (10/11) and N332 (9/11), which are known to be critical for the binding of PG9/PG16-like and PGT128-like bNAbs, respectively. We also observed conservation of critical glycans at positions N234 and N276 critical for the interaction with CD4 binding site bNAbs in 8/11 and 11/11 sequences, respectively. We modeled the three-dimensional structure of the 11 HIV-1 envelopes and found that though each had structural differences, the critical residues were mostly present on the surface of the Env structures. The identified critical residues are proposed as candidates for further evaluation as bNAb epitopes." @default.
• W2896935255 created "2018-10-26" @default.
• W2896935255 creator A5001966018 @default.
• W2896935255 creator A5007960483 @default.
• W2896935255 creator A5023267495 @default.
• W2896935255 creator A5028930914 @default.
• W2896935255 creator A5046296775 @default.
• W2896935255 creator A5053298608 @default.
• W2896935255 creator A5057646007 @default.
• W2896935255 creator A5064585599 @default.
• W2896935255 creator A5076624513 @default.
• W2896935255 creator A5080537538 @default.
• W2896935255 creator A5083948343 @default.
• W2896935255 creator A5085964904 @default.
• W2896935255 date "2019-02-01" @default.
• W2896935255 modified "2023-09-24" @default.
• W2896935255 title "Mapping of Neutralizing Antibody Epitopes on the Envelope of Viruses Obtained from Plasma Samples Exhibiting Broad Cross-Clade Neutralization Potential Against HIV-1" @default.
• W2896935255 cites W111678634 @default.
• W2896935255 cites W1533750546 @default.
• W2896935255 cites W1623081601 @default.
• W2896935255 cites W1965019797 @default.
• W2896935255 cites W1966998384 @default.
• W2896935255 cites W1969156908 @default.
• W2896935255 cites W1975020396 @default.
• W2896935255 cites W1978398372 @default.
• W2896935255 cites W1992888167 @default.
• W2896935255 cites W2003051762 @default.
• W2896935255 cites W2014764918 @default.
• W2896935255 cites W2037320559 @default.
• W2896935255 cites W2038821549 @default.
• W2896935255 cites W2041161883 @default.
• W2896935255 cites W2056710036 @default.
• W2896935255 cites W2057119574 @default.
• W2896935255 cites W2060163862 @default.
• W2896935255 cites W2069826954 @default.
• W2896935255 cites W2070086938 @default.
• W2896935255 cites W2072023931 @default.
• W2896935255 cites W2074637429 @default.
• W2896935255 cites W2074986801 @default.
• W2896935255 cites W2078437475 @default.
• W2896935255 cites W2081539383 @default.
• W2896935255 cites W2084310667 @default.
• W2896935255 cites W2088573476 @default.
• W2896935255 cites W2088742233 @default.
• W2896935255 cites W2089135598 @default.
• W2896935255 cites W2096025413 @default.
• W2896935255 cites W2100316154 @default.
• W2896935255 cites W2100547358 @default.
• W2896935255 cites W2108868448 @default.
• W2896935255 cites W2110298304 @default.
• W2896935255 cites W2113236498 @default.
• W2896935255 cites W2113963476 @default.
• W2896935255 cites W2114077050 @default.
• W2896935255 cites W2122936417 @default.
• W2896935255 cites W2125692679 @default.
• W2896935255 cites W2128579789 @default.
• W2896935255 cites W2131034616 @default.
• W2896935255 cites W2131370652 @default.
• W2896935255 cites W2133233128 @default.
• W2896935255 cites W2145462968 @default.
• W2896935255 cites W2146704167 @default.
• W2896935255 cites W2148072080 @default.
• W2896935255 cites W2148245437 @default.
• W2896935255 cites W2149525061 @default.
• W2896935255 cites W2150001263 @default.
• W2896935255 cites W2155021935 @default.
• W2896935255 cites W2157711997 @default.
• W2896935255 cites W2239363967 @default.
• W2896935255 cites W2259177282 @default.
• W2896935255 cites W2260088076 @default.
• W2896935255 cites W2290769891 @default.
• W2896935255 cites W2312419943 @default.
• W2896935255 cites W2332167798 @default.
• W2896935255 cites W2381153372 @default.
• W2896935255 cites W2401613264 @default.
• W2896935255 cites W2469710699 @default.
• W2896935255 cites W2474704550 @default.
• W2896935255 cites W2557191642 @default.
• W2896935255 cites W2607071575 @default.
• W2896935255 cites W2608032033 @default.
• W2896935255 cites W814539720 @default.
• W2896935255 cites W86613546 @default.
• W2896935255 doi "https://doi.org/10.1089/aid.2018.0224" @default.
• W2896935255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6909397" @default.
• W2896935255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30328700" @default.
• W2896935255 hasPublicationYear "2019" @default.
• W2896935255 type Work @default.
• W2896935255 sameAs 2896935255 @default.
• W2896935255 citedByCount "3" @default.
• W2896935255 countsByYear W28969352552020 @default.
• W2896935255 crossrefType "journal-article" @default.
• W2896935255 hasAuthorship W2896935255A5001966018 @default.
• W2896935255 hasAuthorship W2896935255A5007960483 @default.
• W2896935255 hasAuthorship W2896935255A5023267495 @default.
• W2896935255 hasAuthorship W2896935255A5028930914 @default.
• W2896935255 hasAuthorship W2896935255A5046296775 @default.
• W2896935255 hasAuthorship W2896935255A5053298608 @default.
• W2896935255 hasAuthorship W2896935255A5057646007 @default.
• W2896935255 hasAuthorship W2896935255A5064585599 @default.
• W2896935255 hasAuthorship W2896935255A5076624513 @default.

• next