FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896935457> ?p ?o ?g. }

• W2896935457 abstract "Currently, neoadjuvant chemoradiotherapy (CRT) followed by radical surgery is the standard of care for locally advanced rectal cancer. However, to the best of our knowledge, there are no effective biomarkers for predicting patients who may benefit from neoadjuvant treatment. The aim of the current study was to screen potential crucial genes and pathways associated with the response to CRT in rectal cancer, and provide valid biological information to assist further investigation of CRT optimization. In the current study, differentially expressed (DE) genes were identified from the tumor samples of responders and non-responders to neoadjuvant CRT in the GSE35452 gene expression profile. Seven hub genes and one significant module were identified from the protein-protein interaction (PPI) network. Functional enrichment analysis of all the DE genes and the hub genes, retrieved from PPI network analysis, revealed their associations with CRT response. Genes were identified that may be used to discriminate patients who would or would not clinically benefit from neoadjuvant CRT. Several important pathways enriched by the DE genes, hub genes and selected module were identified, and revealed to be closely associated with radiation response, including excision repair, homologous recombination, Ras signaling pathway, the forkhead box O signaling pathway, focal adhesion and the Wnt signaling pathway. In conclusion, the current study demonstrated that the identified gene signatures and pathways may be used as molecular biomarkers for predicting CRT response. Furthermore, combinations of these biomarkers may be helpful for optimizing CRT treatment and promoting understanding of the molecular basis of response differences; this needs to be confirmed by further experiments." @default.
• W2896935457 created "2018-10-26" @default.
• W2896935457 creator A5022283225 @default.
• W2896935457 creator A5027962256 @default.
• W2896935457 creator A5050701259 @default.
• W2896935457 creator A5058212805 @default.
• W2896935457 creator A5065815493 @default.
• W2896935457 creator A5074147654 @default.
• W2896935457 creator A5091226105 @default.
• W2896935457 date "2018-10-18" @default.
• W2896935457 modified "2023-10-14" @default.
• W2896935457 title "Identification of potential genes and pathways for response prediction of neoadjuvant chemoradiotherapy in patients with rectal cancer by systemic biological analysis" @default.
• W2896935457 cites W1540375156 @default.
• W2896935457 cites W1964130663 @default.
• W2896935457 cites W1966549638 @default.
• W2896935457 cites W2002115702 @default.
• W2896935457 cites W2002786330 @default.
• W2896935457 cites W2008916276 @default.
• W2896935457 cites W2025498302 @default.
• W2896935457 cites W2025828670 @default.
• W2896935457 cites W2047998870 @default.
• W2896935457 cites W2049048127 @default.
• W2896935457 cites W2050365174 @default.
• W2896935457 cites W2051667674 @default.
• W2896935457 cites W2065571847 @default.
• W2896935457 cites W2070771998 @default.
• W2896935457 cites W2074831400 @default.
• W2896935457 cites W2092229754 @default.
• W2896935457 cites W2093879174 @default.
• W2896935457 cites W2096173332 @default.
• W2896935457 cites W2103223723 @default.
• W2896935457 cites W2107296273 @default.
• W2896935457 cites W2114859007 @default.
• W2896935457 cites W2116343100 @default.
• W2896935457 cites W2119782683 @default.
• W2896935457 cites W2120296479 @default.
• W2896935457 cites W2122683221 @default.
• W2896935457 cites W2131865610 @default.
• W2896935457 cites W2133436567 @default.
• W2896935457 cites W2138793275 @default.
• W2896935457 cites W2141077147 @default.
• W2896935457 cites W2141280806 @default.
• W2896935457 cites W2146512944 @default.
• W2896935457 cites W2151252396 @default.
• W2896935457 cites W2158012267 @default.
• W2896935457 cites W2159482845 @default.
• W2896935457 cites W2203397514 @default.
• W2896935457 cites W2248674868 @default.
• W2896935457 cites W2328046081 @default.
• W2896935457 cites W2337876199 @default.
• W2896935457 cites W2418274023 @default.
• W2896935457 cites W2560504961 @default.
• W2896935457 cites W2586403573 @default.
• W2896935457 cites W2591308199 @default.
• W2896935457 cites W2594373254 @default.
• W2896935457 cites W2741127900 @default.
• W2896935457 cites W2752272421 @default.
• W2896935457 cites W4231824804 @default.
• W2896935457 cites W59412852 @default.
• W2896935457 doi "https://doi.org/10.3892/ol.2018.9598" @default.
• W2896935457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313202" @default.
• W2896935457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30655792" @default.
• W2896935457 hasPublicationYear "2018" @default.
• W2896935457 type Work @default.
• W2896935457 sameAs 2896935457 @default.
• W2896935457 citedByCount "1" @default.
• W2896935457 countsByYear W28969354572021 @default.
• W2896935457 crossrefType "journal-article" @default.
• W2896935457 hasAuthorship W2896935457A5022283225 @default.
• W2896935457 hasAuthorship W2896935457A5027962256 @default.
• W2896935457 hasAuthorship W2896935457A5050701259 @default.
• W2896935457 hasAuthorship W2896935457A5058212805 @default.
• W2896935457 hasAuthorship W2896935457A5065815493 @default.
• W2896935457 hasAuthorship W2896935457A5074147654 @default.
• W2896935457 hasAuthorship W2896935457A5091226105 @default.
• W2896935457 hasBestOaLocation W28969354571 @default.
• W2896935457 hasConcept C104317684 @default.
• W2896935457 hasConcept C121608353 @default.
• W2896935457 hasConcept C137620995 @default.
• W2896935457 hasConcept C143998085 @default.
• W2896935457 hasConcept C150194340 @default.
• W2896935457 hasConcept C2778424827 @default.
• W2896935457 hasConcept C2781018059 @default.
• W2896935457 hasConcept C29537977 @default.
• W2896935457 hasConcept C502942594 @default.
• W2896935457 hasConcept C526805850 @default.
• W2896935457 hasConcept C54355233 @default.
• W2896935457 hasConcept C60644358 @default.
• W2896935457 hasConcept C62478195 @default.
• W2896935457 hasConcept C67082663 @default.
• W2896935457 hasConcept C70721500 @default.
• W2896935457 hasConcept C71924100 @default.
• W2896935457 hasConcept C86803240 @default.
• W2896935457 hasConcept C9927688 @default.
• W2896935457 hasConceptScore W2896935457C104317684 @default.
• W2896935457 hasConceptScore W2896935457C121608353 @default.
• W2896935457 hasConceptScore W2896935457C137620995 @default.
• W2896935457 hasConceptScore W2896935457C143998085 @default.
• W2896935457 hasConceptScore W2896935457C150194340 @default.
• W2896935457 hasConceptScore W2896935457C2778424827 @default.

• next