FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896940929> ?p ?o ?g. }

• W2896940929 abstract "History of traumatic brain injury (TBI) is highly prevalent in older veterans. TBI is associated with risk of cognitive impairment, but the underlying pathology is not well understood. We conducted a study of remote TBI and Alzheimer's disease (AD) among older veterans living in retirement communities; 155 veterans from the Armed Forces Retirement Home, Washington, DC, and the Veterans Home of California-Yountville. Veterans provided a blood sample, completed a medical and psychiatric history and neuropsychological testing. We compared 4 groups: Control (n=57), AD (n=33), TBI-no cognitive impairment (TBI-noCI; n=30), and TBI-cognitive impairment (TBI-CI; n=35). TBI diagnosis was determined by the Ohio State University TBI Questionnaire. In those with TBI, CI was defined as a cognitive composite score > 1 SD below normative values or medical record dementia diagnosis or dementia medication. Blood plasma was analyzed across the four groups using the Quanterix Simoa Human Neurology 4-Plex, which measures neurofilament light (NFL), total tau, glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase (UCHL1). Veterans were, on average, 79 years old, mostly male, and had completed 15 years of education. The Table shows group differences on demographics and medical and psychiatric history. Within the participants with TBI, 78% reported loss of consciousness, and 35% had a history of moderate/severe TBI. Mean interval from first TBI to study visit was 51 years, and 88% of veterans had remote TBI (>2 years before visit). In preliminary analyses, none of the groups differed significantly from each other in total tau, NFL, or UCHL1 concentrations. GFAP concentrations were elevated in veterans with AD compared to the other three groups. Further analyses of blood-based biomarkers including amyloid beta and exosomal phospho-tau may help elucidate differences between these TBI and cognitive groups. Our preliminary results suggest that veterans with remote TBI, including those with versus without cognitive impairment, may not differ from veterans without TBI on blood plasma levels of proteins associated with acute TBI. Further investigation of other markers may help determine the underlying pathology of remote TBI and related CI." @default.
• W2896940929 created "2018-10-26" @default.
• W2896940929 creator A5004714555 @default.
• W2896940929 creator A5005597929 @default.
• W2896940929 creator A5038974466 @default.
• W2896940929 creator A5075510618 @default.
• W2896940929 date "2018-07-01" @default.
• W2896940929 modified "2023-10-16" @default.
• W2896940929 title "F5‐06‐04: BLOOD‐BASED BIOMARKER PROFILE OF OLDER VETERANS WITH REMOTE TBI" @default.
• W2896940929 doi "https://doi.org/10.1016/j.jalz.2018.06.2991" @default.
• W2896940929 hasPublicationYear "2018" @default.
• W2896940929 type Work @default.
• W2896940929 sameAs 2896940929 @default.
• W2896940929 citedByCount "0" @default.
• W2896940929 crossrefType "journal-article" @default.
• W2896940929 hasAuthorship W2896940929A5004714555 @default.
• W2896940929 hasAuthorship W2896940929A5005597929 @default.
• W2896940929 hasAuthorship W2896940929A5038974466 @default.
• W2896940929 hasAuthorship W2896940929A5075510618 @default.
• W2896940929 hasConcept C118552586 @default.
• W2896940929 hasConcept C126322002 @default.
• W2896940929 hasConcept C14216870 @default.
• W2896940929 hasConcept C169900460 @default.
• W2896940929 hasConcept C1862650 @default.
• W2896940929 hasConcept C2779134260 @default.
• W2896940929 hasConcept C2779483572 @default.
• W2896940929 hasConcept C2781017439 @default.
• W2896940929 hasConcept C536788834 @default.
• W2896940929 hasConcept C71924100 @default.
• W2896940929 hasConcept C89256451 @default.
• W2896940929 hasConceptScore W2896940929C118552586 @default.
• W2896940929 hasConceptScore W2896940929C126322002 @default.
• W2896940929 hasConceptScore W2896940929C14216870 @default.
• W2896940929 hasConceptScore W2896940929C169900460 @default.
• W2896940929 hasConceptScore W2896940929C1862650 @default.
• W2896940929 hasConceptScore W2896940929C2779134260 @default.
• W2896940929 hasConceptScore W2896940929C2779483572 @default.
• W2896940929 hasConceptScore W2896940929C2781017439 @default.
• W2896940929 hasConceptScore W2896940929C536788834 @default.
• W2896940929 hasConceptScore W2896940929C71924100 @default.
• W2896940929 hasConceptScore W2896940929C89256451 @default.
• W2896940929 hasIssue "7S_Part_31" @default.
• W2896940929 hasLocation W28969409291 @default.
• W2896940929 hasOpenAccess W2896940929 @default.
• W2896940929 hasPrimaryLocation W28969409291 @default.
• W2896940929 hasRelatedWork W2128152952 @default.
• W2896940929 hasRelatedWork W2171968088 @default.
• W2896940929 hasRelatedWork W2182160216 @default.
• W2896940929 hasRelatedWork W2383651644 @default.
• W2896940929 hasRelatedWork W2416973815 @default.
• W2896940929 hasRelatedWork W2430477239 @default.
• W2896940929 hasRelatedWork W2538432766 @default.
• W2896940929 hasRelatedWork W2952807869 @default.
• W2896940929 hasRelatedWork W3015876505 @default.
• W2896940929 hasRelatedWork W3184290692 @default.
• W2896940929 hasVolume "14" @default.
• W2896940929 isParatext "false" @default.
• W2896940929 isRetracted "false" @default.
• W2896940929 magId "2896940929" @default.
• W2896940929 workType "article" @default.