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• W2896941725 abstract "MicroRNA-647 (miR-647) has been reported to repress cell tumorigenic phenotype, while the function of miR-647 in non-small cell lung cancer was obscure.The effect of miR-647 and TRAF2 on A549 and H1299 cells was explored through Methyl thiazolyl tetrazolium (MTT) assay, colony formation and cell cycle assays. Luciferase reporter assays, reverse transcription quantitative PCR (RT-qPCR) and Western blot assay were carried out to determine that TRAF2 is directly regulated by miR-647. The effect of miR-647/TRAF2 axis on p65 protein level in nucleus or total was detected by Western blot assay.Here, we found that miR-647 was high expression in tumor that under argon-helium cryoablation treatment in contrast to the tumor under non argon-helium cryoablation treatment and inhibited cell proliferation of A549 and H1299 cells by inducing G1-S transition. TRAF2 was confirmed as a target of miR-647. TRAF2 overexpression partially rescued the suppressive function of miR-647 in A549 and H1299 cells. Moreover, we found that miR-647 repressed lung carcinogenesis by attenuating NF-κB pathway.In all, our study demonstrates that miR-647 functions as tumor suppressor via targeting and down-regulating the expression of TRAF2 and NF-κB signaling pathway in non-small cell lung cancer." @default.
• W2896941725 created "2018-10-26" @default.
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• W2896941725 date "2018-10-01" @default.
• W2896941725 modified "2023-10-18" @default.
• W2896941725 title "MicroRNA-647 promotes the therapeutic effectiveness of argon&ndash;helium cryoablation and inhibits cell proliferation through targeting TRAF2 via the NF-&kappa;B signaling pathway in non-small cell lung cancer" @default.
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• W2896941725 doi "https://doi.org/10.2147/ott.s159337" @default.
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