FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896943598> ?p ?o ?g. }

• W2896943598 abstract "Alzheimer's disease (AD) is a public health issue that generally affects older adults. This disease is a brain disorder that involve the accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles. However, neuroinflammation also contributes to the pathogenesis of the disease. IL-6 has been studied to have both pro-inflammatory and anti-inflammatory responses. Thus, there is an interest in uncovering which immunological biomarkers could predict atrophy across the AD spectrum. Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) was used to examine immunological biomarkers measured in the cerebrospinal fluid, including cytokines such as interleukins, that could predict atrophy in the medial temporal lobe, parietal lobe, and frontal insular lobe across diagnostic groups. These diagnostic groups consisted of Cognitive Normal (CN), Mild Cognitive Impairment (MCI), and AD participants. Regression analysis was conducted to determine the relationship. Age, sex, education and BMI were set as covariates. Macrophage inflammatory protein 3α appeared to have the most significant association in atrophy across diagnostic groups overall and in the medial temporal lobe from 33.02 voxels in CN participants to -21.91 voxels in AD participants [F=10.95, R2=0.505, p<0.001]. Interleukin 23 appeared to have the second most significant association in atrophy across diagnostic groups overall, in the frontal insular from 123.96 voxels in CN participants to -8.94 voxels in AD participants [F=7.61, R2=0.406, p<0.001] and in the parietal lobe from 537.49 voxels in CN participants to -121.92 voxels in AD participants [F=8.84, R2= 0.443, p<0.001]. Macrophage inflammatory protein 3α, also known as CCL20, and its expression elevated following traumatic brain injury which is associated with AD. IL-23 has been reviewed to be an important mediator of neuroinflammation in other studies. However, more research is necessary to better understand their role in AD." @default.
• W2896943598 created "2018-10-26" @default.
• W2896943598 creator A5048893803 @default.
• W2896943598 creator A5052668077 @default.
• W2896943598 creator A5073909692 @default.
• W2896943598 date "2018-07-01" @default.
• W2896943598 modified "2023-10-16" @default.
• W2896943598 title "P2‐197: RELATIONSHIP BETWEEN IMMUNOLOGICAL BIOMARKERS AND CEREBRAL ATROPHY ACROSS THE AD SPECTRUM" @default.
• W2896943598 doi "https://doi.org/10.1016/j.jalz.2018.06.884" @default.
• W2896943598 hasPublicationYear "2018" @default.
• W2896943598 type Work @default.
• W2896943598 sameAs 2896943598 @default.
• W2896943598 citedByCount "0" @default.
• W2896943598 crossrefType "journal-article" @default.
• W2896943598 hasAuthorship W2896943598A5048893803 @default.
• W2896943598 hasAuthorship W2896943598A5052668077 @default.
• W2896943598 hasAuthorship W2896943598A5073909692 @default.
• W2896943598 hasConcept C126322002 @default.
• W2896943598 hasConcept C126838900 @default.
• W2896943598 hasConcept C142724271 @default.
• W2896943598 hasConcept C143409427 @default.
• W2896943598 hasConcept C15744967 @default.
• W2896943598 hasConcept C169760540 @default.
• W2896943598 hasConcept C200134340 @default.
• W2896943598 hasConcept C2777127467 @default.
• W2896943598 hasConcept C2778180168 @default.
• W2896943598 hasConcept C2778186239 @default.
• W2896943598 hasConcept C2781099131 @default.
• W2896943598 hasConcept C2781172350 @default.
• W2896943598 hasConcept C2781192897 @default.
• W2896943598 hasConcept C54170458 @default.
• W2896943598 hasConcept C58693492 @default.
• W2896943598 hasConcept C71924100 @default.
• W2896943598 hasConceptScore W2896943598C126322002 @default.
• W2896943598 hasConceptScore W2896943598C126838900 @default.
• W2896943598 hasConceptScore W2896943598C142724271 @default.
• W2896943598 hasConceptScore W2896943598C143409427 @default.
• W2896943598 hasConceptScore W2896943598C15744967 @default.
• W2896943598 hasConceptScore W2896943598C169760540 @default.
• W2896943598 hasConceptScore W2896943598C200134340 @default.
• W2896943598 hasConceptScore W2896943598C2777127467 @default.
• W2896943598 hasConceptScore W2896943598C2778180168 @default.
• W2896943598 hasConceptScore W2896943598C2778186239 @default.
• W2896943598 hasConceptScore W2896943598C2781099131 @default.
• W2896943598 hasConceptScore W2896943598C2781172350 @default.
• W2896943598 hasConceptScore W2896943598C2781192897 @default.
• W2896943598 hasConceptScore W2896943598C54170458 @default.
• W2896943598 hasConceptScore W2896943598C58693492 @default.
• W2896943598 hasConceptScore W2896943598C71924100 @default.
• W2896943598 hasIssue "7S_Part_14" @default.
• W2896943598 hasLocation W28969435981 @default.
• W2896943598 hasOpenAccess W2896943598 @default.
• W2896943598 hasPrimaryLocation W28969435981 @default.
• W2896943598 hasRelatedWork W1970285134 @default.
• W2896943598 hasRelatedWork W2011343075 @default.
• W2896943598 hasRelatedWork W2035683295 @default.
• W2896943598 hasRelatedWork W2050461197 @default.
• W2896943598 hasRelatedWork W2093168495 @default.
• W2896943598 hasRelatedWork W2101362126 @default.
• W2896943598 hasRelatedWork W2106753219 @default.
• W2896943598 hasRelatedWork W2151896186 @default.
• W2896943598 hasRelatedWork W2414194418 @default.
• W2896943598 hasRelatedWork W2762387711 @default.
• W2896943598 hasVolume "14" @default.
• W2896943598 isParatext "false" @default.
• W2896943598 isRetracted "false" @default.
• W2896943598 magId "2896943598" @default.
• W2896943598 workType "article" @default.