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- W2896943939 abstract "Abstract Capillary electrophoresis-mass spectrometry (CE-MS) is the result of hyphenating a separation technique based on the movement of ions under electrophoretic and/or electro-osmotic forces produced by the application of an electric field with a mass spectrometer. The technique is especially well suited for polar and ionic compounds in complex polar matrices, increasing the metabolite coverage of LC-MS and GC-MS. The present chapter describes the basis of CE, focusing on capillary zone electrophoresis and its instrumentation. It includes the main conditions that can be modified to optimize the separation; as well as CE special conditions for coupling to MS with benefits and drawbacks as compared to other separation techniques. After establishing the appropriate instrumental set up of a metabolomics experiment, every step in the workflow is described, from experimental design, sample pretreatment, analytical conditions, data treatment, metabolite identification, to biological interpretation. Along the text, the reader will find similarities and differences in this workflow with other separation techniques (LC and GC) used with the same purpose. Biomedical applications of CE-MS for metabolic phenotyping are described in detail in this chapter from different points of view: (i) a chart illustrates the contributions of different metabolite classes within the general term “CE-metabolome” (ii) a table describes several alterations of metabolites such as acetylation, methylation, and phosphorylation that can be detected with CE-MS contributing to the description of the so-called epimetabolome (iii) findings regarding metabolites that have been seen altered in specific diseases such as cancer, metabolic disorders, neurodegenerative diseases, among others, detected by CE-MS, are included." @default.
- W2896943939 created "2018-10-26" @default.
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- W2896943939 date "2019-01-01" @default.
- W2896943939 modified "2023-10-01" @default.
- W2896943939 title "Metabolic Phenotyping Using Capillary Electrophoresis Mass Spectrometry" @default.
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- W2896943939 doi "https://doi.org/10.1016/b978-0-12-812293-8.00005-0" @default.
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