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- W2896945710 abstract "Accumulating evidence suggests that child neurodevelopment and life course mental health begins in utero, with the offspring of mothers who experienced adverse childhood experiences (ACEs) at increased risk for adversity. Although many mechanisms of transmission have been considered, this study focuses on the hypothalamic-pituitary-adrenal axis. Increasing maternal cortisol is necessary for fetal development over the course of pregnancy. Maternal hair cortisol (HC) levels in the second trimester have previously been associated with perinatal stressors and are negatively correlated with gestational age (GA) at delivery and birth weight (BW). We hypothesized that expectant mothers with elevated ACE scores would have elevated HC and perceived stress and that the elevated HC and stress would be negatively associated with GA, BW, and infant behavior." @default.
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- W2896945710 date "2018-10-01" @default.
- W2896945710 modified "2023-09-26" @default.
- W2896945710 title "3.64 Intergenerational Transmission of Adversity: A Focus on Perinatal Stress, the Hypothalamic-Pituitary-Adrenal (HPA) Axis, and Infant Neurodevelopment" @default.
- W2896945710 doi "https://doi.org/10.1016/j.jaac.2018.09.222" @default.
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