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- W2896945901 abstract "Oleanolic acid (OA) and echinocystic acid (EA), two naturally occurring pentacyclic oleanane triterpenes, are gaining increasing attention due to their promising pharmacological activities. Conjugation with amphiphilic α(β)-cyclodextrin (CD) via “click chemistry” can improve their solubility and anti-HCV entry potency. In the present work, four water-soluble β-CD-pentacyclic triterpene conjugates were designed and synthesized, in which OA and EA was coupled to one of the primary hydroxyl groups of β-CD via ester and amide bonds. The structures of the conjugates were unambiguously determined by 1H NMR, 13C NMR and HRMS or MALDI-TOF-MS. All the conjugates showed lower hydrophobicity (AlogP) than their parent compounds and no significant cytotoxicity was found to HL-60, A549, Hela and Bel-7402 cells at concentrations up to 10 μmol/L. Further anti-HCV entry activity and mechanism studies are under way in our laboratory." @default.
- W2896945901 created "2018-10-26" @default.
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- W2896945901 date "2019-03-01" @default.
- W2896945901 modified "2023-10-18" @default.
- W2896945901 title "Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates" @default.
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- W2896945901 doi "https://doi.org/10.1016/j.cclet.2018.10.009" @default.
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