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- W2896946091 abstract "Plasma Aβ levels are altered in patients with Alzheimer's dementia (AD) and amnestic mild cognitive impairment (MCI) and have been shown to associate with cognition and CSF amyloid and tau, and cerebral amyloid deposition (Hanon (2018), Alz & Dem; Janelidze (2017), Sci Rep; Nabers (2018), EMBO Mol Med). We sought to evaluate the association of plasma Aβ with both cerebral amyloid and tau deposition in a cohort of cognitively normal older adults (CN) and MCI and AD patients. 47 participants (20 CN, 11 MCI, 16 AD) underwent amyloid PET imaging with either [18F]Florbetapir or [18F]Florbetaben and a blood draw. Free and total plasma Aβ40 and Aβ42 were assessed using a validated assay, ABtest, developed by Araclon Biotech (Perez-Grijalba et al (2016) JAD). Amyloid PET scans were pre-processed with standard methods and transformed into Centiloids (Klunk (2015) Alz & Dem). 41 participants (19 CN, 10 MCI, 12 AD) also underwent a tau PET scan with [18F]flortaucipir. Tau PET scans were processed using standard techniques and intensity normalized to mean cerebellar crus uptake to create standardized uptake value ratio (SUVR) images. The relationships between the ratios of free plasma Aβ42 to free Aβ40 (F42:F40) and total plasma Aβ42 to total Aβ40 (T42:T40) and cerebral amyloid and tau were evaluated on a voxel-wise basis using SPM8, covaried for age and sex. Results were masked for grey plus white matter and displayed at a cluster-wise threshold of p<0.05 with family-wise error (FWE) correction. Lower plasma Aβ ratios were associated with increased cerebral amyloid and tau deposition (Figure 1). Specifically, the F42:F40 ratio was associated with amyloid deposition in the bilateral frontal lobe (Figure 1A) and tau deposition in the bilateral temporal lobe (Figure 1C). The T42:T40 ratio was associated with amyloid deposition in the frontal, parietal, and temporal lobes (Figure 1B) and tau deposition in the bilateral temporal lobes and left anterior cingulate and frontal lobe (Figure 1D)." @default.
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- W2896946091 date "2018-07-01" @default.
- W2896946091 modified "2023-10-16" @default.
- W2896946091 title "P4‐273: ASSOCIATION BETWEEN PLASMA Aβ LEVELS AND CEREBRAL AMYLOID AND TAU DEPOSITION" @default.
- W2896946091 doi "https://doi.org/10.1016/j.jalz.2018.07.095" @default.
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