FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896947430> ?p ?o ?g. }

• W2896947430 endingPage "e631" @default.
• W2896947430 startingPage "e631" @default.
• W2896947430 abstract "Hematologic toxicity (HT) during pelvic chemoradiation may cause treatment modifications or delays. There is emerging interest in using PET-defined regions of active bone marrow (ABM) to spare hematopoetically active bone marrow. However, the optimal methods for defining ABM and its dosimetric parameters are undefined. In this study, a comprehensive analysis of dosimetric predictors for two commonly used ABM metrics is performed and compared to total bone as a surrogate for BM. Thirty-one patients treated for cervical cancer from 5/2011 – 10/2017 were reviewed. All patients received pelvic radiation using IMRT (12 patients, 38.7%) or 3D-CRT (19 patients, 61.3%) with concurrent cisplatin. Pelvic BM (PBM) was defined using a total bone surrogate including L4, L5, proximal femur to lesser trochanter, ilium, sacrum, ischium, and pubis. Whole body mean SUV ABM (WB-ABM) was defined as the ABM greater than the total body mean SUV minus brain. Bone mean SUV ABM (B-ABM) was defined analogous to the NRG-GY006 protocol as ABM with an SUV greater than the mean SUV of bone. Receiver Operating Characteristic (ROC) curve were used to assess optimal cutpoint criteria for grade 3+ HT for any cell line based on the CTCAEv4. Conventional dosimetric parameters (mean dose, V10, V20, V40) to PBM, WB-ABM, and B-ABM were assessed as well as the absolute volume (cc) spared 10, 20, and 40 Gy for each defined volume. The volumes of ABM were compared using a paired t-test. At least one grade 3+ HT occurred in 26 patients (83.9%). The B-ABM volumes (mean 598 cc, 415-875 cc) were significantly smaller than the WB-ABM volumes (mean 1078 cc, 481-1603 cc) (p<0.0001). The mean dose, V10, V20, V40, volume spared 10 Gy and 20 Gy of WB-ABM, B-ABM, and PBM; as well as volume spared 40 Gy of B-ABM and PBM, did not predict HT (table). The absolute volume of WB-ABM spared 40 Gy (<853cc, AUC 0.777, p=0.0016) was the best predictor for grade 3+ HT. In patients with <742 cc WB-ABM spared 40 Gy, 16/16 (100%) had grade 3+ HT compared to 10/15 (67%) patients with >742 cc spared 40 Gy (p=0.04). Using PET to define metabolically active BM is feasible. Thresholding ABM using the mean SUV of bone (B-ABM) yields volumes that are significantly smaller than whole body mean (WB-ABM) volumes and may not predict for grade 3+HT. This analysis suggests that absolute volume of WB-ABM spared 40 Gy (>742 cc) is a strong predictor of grade 3+HT and should be further evaluated for clinical use.Abstract TU_16_3476: Table 1ROC Analysis for grade 3+ HTPelvic BonepWB-ABMpB-ABMpMean dose0.6540.15010.5850.42460.5770.467V100.5380.76220.5270.82260.5540.682V200.6690.1320.6350.2280.560.589V400.510.5380.7430.5120.911cc spared 10 Gy0.5850.54060.6770.120.5770.521cc spared 20 Gy0.5040.9770.5850.480.5080.951cc spared 40 Gy0.7310.03810.7770.00160.70.061 Open table in a new tab" @default.
• W2896947430 created "2018-10-26" @default.
• W2896947430 creator A5003321146 @default.
• W2896947430 creator A5011965791 @default.
• W2896947430 creator A5019136436 @default.
• W2896947430 creator A5020705872 @default.
• W2896947430 creator A5031132761 @default.
• W2896947430 creator A5052058020 @default.
• W2896947430 creator A5055286138 @default.
• W2896947430 creator A5073243721 @default.
• W2896947430 date "2018-11-01" @default.
• W2896947430 modified "2023-09-26" @default.
• W2896947430 title "A Comparison of PET-Defined, Active Bone Marrow Threshold Methods in Predicting Acute Hematologic Toxicity in Cervical Cancer Patients Undergoing Definitive Chemoradiation" @default.
• W2896947430 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1723" @default.
• W2896947430 hasPublicationYear "2018" @default.
• W2896947430 type Work @default.
• W2896947430 sameAs 2896947430 @default.
• W2896947430 citedByCount "0" @default.
• W2896947430 crossrefType "journal-article" @default.
• W2896947430 hasAuthorship W2896947430A5003321146 @default.
• W2896947430 hasAuthorship W2896947430A5011965791 @default.
• W2896947430 hasAuthorship W2896947430A5019136436 @default.
• W2896947430 hasAuthorship W2896947430A5020705872 @default.
• W2896947430 hasAuthorship W2896947430A5031132761 @default.
• W2896947430 hasAuthorship W2896947430A5052058020 @default.
• W2896947430 hasAuthorship W2896947430A5055286138 @default.
• W2896947430 hasAuthorship W2896947430A5073243721 @default.
• W2896947430 hasBestOaLocation W28969474301 @default.
• W2896947430 hasConcept C121608353 @default.
• W2896947430 hasConcept C126322002 @default.
• W2896947430 hasConcept C126838900 @default.
• W2896947430 hasConcept C2778220009 @default.
• W2896947430 hasConcept C2778357063 @default.
• W2896947430 hasConcept C2778541249 @default.
• W2896947430 hasConcept C2780007613 @default.
• W2896947430 hasConcept C2989005 @default.
• W2896947430 hasConcept C71924100 @default.
• W2896947430 hasConceptScore W2896947430C121608353 @default.
• W2896947430 hasConceptScore W2896947430C126322002 @default.
• W2896947430 hasConceptScore W2896947430C126838900 @default.
• W2896947430 hasConceptScore W2896947430C2778220009 @default.
• W2896947430 hasConceptScore W2896947430C2778357063 @default.
• W2896947430 hasConceptScore W2896947430C2778541249 @default.
• W2896947430 hasConceptScore W2896947430C2780007613 @default.
• W2896947430 hasConceptScore W2896947430C2989005 @default.
• W2896947430 hasConceptScore W2896947430C71924100 @default.
• W2896947430 hasIssue "3" @default.
• W2896947430 hasLocation W28969474301 @default.
• W2896947430 hasOpenAccess W2896947430 @default.
• W2896947430 hasPrimaryLocation W28969474301 @default.
• W2896947430 hasRelatedWork W2083192741 @default.
• W2896947430 hasRelatedWork W2083739207 @default.
• W2896947430 hasRelatedWork W2092108413 @default.
• W2896947430 hasRelatedWork W2366537657 @default.
• W2896947430 hasRelatedWork W2392526455 @default.
• W2896947430 hasRelatedWork W2555594647 @default.
• W2896947430 hasRelatedWork W2918978802 @default.
• W2896947430 hasRelatedWork W3115851997 @default.
• W2896947430 hasRelatedWork W4225405029 @default.
• W2896947430 hasRelatedWork W4237195532 @default.
• W2896947430 hasVolume "102" @default.
• W2896947430 isParatext "false" @default.
• W2896947430 isRetracted "false" @default.
• W2896947430 magId "2896947430" @default.
• W2896947430 workType "article" @default.