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• W2896947777 abstract "Immune nonresponder (INR) HIV-1-infected subjects are characterized by their inability to reconstitute the CD4+ T cell pool after antiretroviral therapy. This is linked to poor clinical outcome. Mechanisms underlying immune reconstitution failure are poorly understood, although, counterintuitively, INRs often have increased frequencies of circulating CD4+ T cells in the cell cycle. While cycling CD4+ T cells from healthy controls and HIV+ patients with restored CD4+ T cell numbers complete cell division in vitro, cycling CD4+ T cells from INRs do not. Here, we show that cells with the phenotype and transcriptional profile of Tregs were enriched among cycling cells in health and in HIV infection. Yet there were diminished frequencies and numbers of Tregs among cycling CD4+ T cells in INRs, and cycling CD4+ T cells from INR subjects displayed transcriptional profiles associated with the impaired development and maintenance of functional Tregs. Flow cytometric assessment of TGF-β activity confirmed the dysfunction of Tregs in INR subjects. Transcriptional profiling and flow cytometry revealed diminished mitochondrial fitness in Tregs among INRs, and cycling Tregs from INRs had low expression of the mitochondrial biogenesis regulators peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1α) and transcription factor A for mitochondria (TFAM). In vitro exposure to IL-15 allowed cells to complete division, restored the expression of PGC1α and TFAM, and regenerated mitochondrial fitness in the cycling Tregs of INRs. Our data suggest that rescuing mitochondrial function could correct the immune dysfunction characteristic of Tregs in HIV-1-infected subjects who fail to restore CD4+ T cells during antiretroviral therapy." @default.
• W2896947777 created "2018-10-26" @default.
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• W2896947777 date "2018-10-15" @default.
• W2896947777 modified "2023-10-16" @default.
• W2896947777 title "Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction" @default.
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• W2896947777 doi "https://doi.org/10.1172/jci120245" @default.
• W2896947777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205369" @default.
• W2896947777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320604" @default.
• W2896947777 hasPublicationYear "2018" @default.
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