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- W2896950859 abstract "A reduction in protein phosphatase 2A (PP2A) activity is intimately linked to the abnormal hyperphosphorylation of tau and APP in Alzheimer Disease (AD). However, the molecular steps that contribute to PP2A inhibition remain unclear. CIP2A is an endogenous inhibitor of PP2A with increased expression in numerous peripheral tumor tissues. Its role in PP2A regulation in AD brains remains unclarified. The protein levels of CIP2A were detected in the brains of AD and control patients by Western blotting. The effects of CIP2A overexpression on β-amyloidosis, tauopathy and synaptic morphology/function were explored both in cultured neurons and mice through plasmids tranfection or AAV transduction. The cognitive function was observed in the mice through behavior tests. Overexpression of CIP2A resulted in PP2A inhibition, APP and tau hyperphosphorylation and enhancement in APP β-secretion and Aβ production. An increase in CIP2A expression also led to tau mislocalization to dendrites and spines, and synaptic degeneration. In mice, injection of AAV-CIP2A to hippocampal region induced AD-like cognitive deficits, impairments in LTP, and exacerbated AD pathologies at the cellular level in neurons. Consistently, we also found an increase in CIP2A expression in the brains of AD patients as well as in Aβ-incubated primary neurons and APP-overexpressed SY5Y cells. We conclude that CIP2A exacerbates Alzheimer-like pathologies through increasing tau and APP phosphorylation by inhibiting PP2A. Together with the non-essential function for CIP2A in normal adult brain function, these results also indicate CIP2A as a novel AD therapy target." @default.
- W2896950859 created "2018-10-26" @default.
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- W2896950859 date "2018-07-01" @default.
- W2896950859 modified "2023-10-16" @default.
- W2896950859 title "P3‐172: CIP2A‐PP2A SIGNALING CAUSES TAU/APP PHOSPHORYLATION, SYNAPTOPATHY AND MEMORY DEFICITS IN ALZHEIMER'S DISEASE" @default.
- W2896950859 doi "https://doi.org/10.1016/j.jalz.2018.06.1530" @default.
- W2896950859 hasPublicationYear "2018" @default.
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