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- W2896956374 abstract "Synapse dysfunction and loss represent critical early events in the pathophysiology of Alzheimer's disease (AD). While extensive research has elucidated the direct synaptotoxic effects of Amyloid-β (Aβ) oligomers, less is known about how signaling pathways at the synapse are affected by Aβ. A better understanding of the cellular and molecular mechanisms underlying synaptic vulnerability in AD is key to illuminating the determinants of AD susceptibility and will unveil novel therapeutic avenues. Canonical Wnt signaling through the Wnt co-receptor LRP6 has a critical role in maintaining the structural and functional integrity of synaptic connections in the adult brain. Accumulating evidence suggests that deficient Wnt signaling may contribute to AD pathology. In particular, LRP6 deficiency compromises synaptic function and stability, and contributes to Aß production and plaque formation. Here, we review the role of Wnt signaling for synaptic maintenance in the adult brain and the contribution of aberrant Wnt signaling to synaptic degeneration in AD. We place a focus on emerging evidence implicating the LRP6 receptor as an important modulator of AD risk and pathology." @default.
- W2896956374 created "2018-10-26" @default.
- W2896956374 creator A5020195440 @default.
- W2896956374 creator A5037934027 @default.
- W2896956374 date "2018-10-30" @default.
- W2896956374 modified "2023-09-25" @default.
- W2896956374 title "Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor" @default.
- W2896956374 cites W1508675434 @default.
- W2896956374 cites W1554535382 @default.
- W2896956374 cites W1557541313 @default.
- W2896956374 cites W1563440444 @default.
- W2896956374 cites W1589352523 @default.
- W2896956374 cites W1611720630 @default.
- W2896956374 cites W1638088518 @default.
- W2896956374 cites W1645139068 @default.
- W2896956374 cites W1841850981 @default.
- W2896956374 cites W1862417723 @default.
- W2896956374 cites W1884253317 @default.
- W2896956374 cites W1957957030 @default.
- W2896956374 cites W1963836337 @default.
- W2896956374 cites W1966555281 @default.
- W2896956374 cites W1966741769 @default.
- W2896956374 cites W1967073403 @default.
- W2896956374 cites W1968379123 @default.
- W2896956374 cites W1973526162 @default.
- W2896956374 cites W1979283544 @default.
- W2896956374 cites W1980789245 @default.
- W2896956374 cites W1983535614 @default.
- W2896956374 cites W1983712244 @default.
- W2896956374 cites W1983796862 @default.
- W2896956374 cites W1984068399 @default.
- W2896956374 cites W1988994274 @default.
- W2896956374 cites W1989272234 @default.
- W2896956374 cites W1989782611 @default.
- W2896956374 cites W1990752558 @default.
- W2896956374 cites W1993668532 @default.
- W2896956374 cites W1996553105 @default.
- W2896956374 cites W1998179719 @default.
- W2896956374 cites W1998977808 @default.
- W2896956374 cites W1999664376 @default.
- W2896956374 cites W1999794509 @default.
- W2896956374 cites W2000283379 @default.
- W2896956374 cites W2000706612 @default.
- W2896956374 cites W2001750357 @default.
- W2896956374 cites W2002871409 @default.
- W2896956374 cites W2003070434 @default.
- W2896956374 cites W2004486036 @default.
- W2896956374 cites W2004973134 @default.
- W2896956374 cites W2006419043 @default.
- W2896956374 cites W2008315346 @default.
- W2896956374 cites W2009970240 @default.
- W2896956374 cites W2014739744 @default.
- W2896956374 cites W2015197347 @default.
- W2896956374 cites W2015484447 @default.
- W2896956374 cites W2018340606 @default.
- W2896956374 cites W2020291601 @default.
- W2896956374 cites W2020335542 @default.
- W2896956374 cites W2023467539 @default.
- W2896956374 cites W2026854632 @default.
- W2896956374 cites W2031530650 @default.
- W2896956374 cites W2031864556 @default.
- W2896956374 cites W2032465593 @default.
- W2896956374 cites W2032870346 @default.
- W2896956374 cites W2036912839 @default.
- W2896956374 cites W2037062825 @default.
- W2896956374 cites W2047858736 @default.
- W2896956374 cites W2050222746 @default.
- W2896956374 cites W2050543389 @default.
- W2896956374 cites W2051268743 @default.
- W2896956374 cites W2051907575 @default.
- W2896956374 cites W2052870845 @default.
- W2896956374 cites W2054275187 @default.
- W2896956374 cites W2055808176 @default.
- W2896956374 cites W2056516296 @default.
- W2896956374 cites W2057815562 @default.
- W2896956374 cites W2058253080 @default.
- W2896956374 cites W2058371877 @default.
- W2896956374 cites W2058594344 @default.
- W2896956374 cites W2059192659 @default.
- W2896956374 cites W2059928135 @default.
- W2896956374 cites W2061387301 @default.
- W2896956374 cites W2061602279 @default.
- W2896956374 cites W2063808031 @default.
- W2896956374 cites W2064145055 @default.
- W2896956374 cites W2065678033 @default.
- W2896956374 cites W2068107037 @default.
- W2896956374 cites W2072737785 @default.
- W2896956374 cites W2074840951 @default.
- W2896956374 cites W2076155053 @default.
- W2896956374 cites W2079401175 @default.
- W2896956374 cites W2082429191 @default.
- W2896956374 cites W2083236466 @default.
- W2896956374 cites W2084660664 @default.
- W2896956374 cites W2087243986 @default.
- W2896956374 cites W2090277946 @default.
- W2896956374 cites W2095212600 @default.
- W2896956374 cites W2100610042 @default.
- W2896956374 cites W2102038759 @default.
- W2896956374 cites W2102416906 @default.
- W2896956374 cites W2104774845 @default.