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- W2896957788 abstract "An improved and efficient method for the synthesis of panobinostat was developed. The commercially available starting material 4-(chloromethyl)benzaldehyde was converted to ( E)-methyl 3-[4-(chloromethyl)phenyl]acrylate via the Wittig–Horner reaction and was then directly condensed with 2-(2-methyl-1 H-indol-3-yl)ethanamine to afford the key intermediate ( E)-methyl 3-[4-({[2-(2-methyl-1 H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylate in a one-pot synthesis reactor. Subsequently a nucleophilic substitution reaction was carried out smoothly to generate the desired compound. The key intermediate and target compound were characterised by HRMS, 1 H NMR and 13 C NMR. This procedure is operationally simple and would be more suitable for industrial production." @default.
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- W2896957788 date "2018-09-01" @default.
- W2896957788 modified "2023-09-26" @default.
- W2896957788 title "An Improved and Efficient Synthesis of Panobinostat" @default.
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- W2896957788 doi "https://doi.org/10.3184/174751918x15357309308931" @default.
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