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- W2896958674 abstract "CONNECTIONS BETWEEN OBESITY AND COLORECTAL CANCER. THE ROLE OF INFLAMMATION MEDIATED BY GHRELIN AXIS IN ADIPOSE TISSUE (Abstract): Obesity and colorectal cancer are two major global health issues. Although they seem to lack a clear connection, epidemiologic analysis found a significant association. This led to further evaluation and identification of molecular pathways that stand at the basis of these findings. One of them is chronic inflammation, a state associated with obesity and colorectal cancer. Adipose tissue from obese individuals suffers a pathogenic switch responsible for higher inflammatory capacity. This modulates the interplay between inflammation and colorectal cancer cells. Through growth factors and cytokines, adipose tissue creates a favorable microenvironment for tumor development. Our focus is on the ghrelin-growth hormone secretagogue receptor axis which promotes inflammation and has mitogenic and antiapoptotic capacity on cancer cells, acting through various mechanisms including via TNF-α which promotes tumor cell proliferation, growth and metastasis and IL-6, a molecule associated with tumor size and stage in colorectal cancer patients." @default.
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- W2896958674 date "2018-10-02" @default.
- W2896958674 modified "2023-09-28" @default.
- W2896958674 title "CONNECTIONS BETWEEN OBESITY AND COLORECTAL CANCER. THE ROLE OF INFLAMMATION MEDIATED BY GHRELIN AXIS IN THE ADIPOSE TISSUE" @default.
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