FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896959233> ?p ?o ?g. }

• W2896959233 endingPage "5072" @default.
• W2896959233 startingPage "5056" @default.
• W2896959233 abstract "Dysregulated intestinal epithelial apoptosis initiates gut injury, alters the intestinal barrier, and can facilitate bacterial translocation leading to a systemic inflammatory response syndrome (SIRS) and/or multi-organ dysfunction syndrome (MODS). A variety of gastrointestinal disorders, including inflammatory bowel disease, have been linked to intestinal apoptosis. Similarly, intestinal hyperpermeability and gut failure occur in critically ill patients, putting the gut at the center of SIRS pathology. Regulation of apoptosis and immune-modulatory functions have been ascribed to Thirty-eight-negative kinase 1 (TNK1), whose activity is regulated merely by expression. We investigated the effect of TNK1 on intestinal integrity and its role in MODS. TNK1 expression induced crypt-specific apoptosis, leading to bacterial translocation, subsequent septic shock, and early death. Mechanistically, TNK1 expression in vivo resulted in STAT3 phosphorylation, nuclear translocation of p65, and release of IL-6 and TNF-α. A TNF-α neutralizing antibody partially blocked development of intestinal damage. Conversely, gut-specific deletion of TNK1 protected the intestinal mucosa from experimental colitis and prevented cytokine release in the gut. Finally, TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut." @default.
• W2896959233 created "2018-10-26" @default.
• W2896959233 creator A5000188033 @default.
• W2896959233 creator A5001697228 @default.
• W2896959233 creator A5003197421 @default.
• W2896959233 creator A5017368964 @default.
• W2896959233 creator A5022410156 @default.
• W2896959233 creator A5023494828 @default.
• W2896959233 creator A5023643896 @default.
• W2896959233 creator A5024003678 @default.
• W2896959233 creator A5029759771 @default.
• W2896959233 creator A5031900006 @default.
• W2896959233 creator A5033389583 @default.
• W2896959233 creator A5033609356 @default.
• W2896959233 creator A5040259968 @default.
• W2896959233 creator A5051011523 @default.
• W2896959233 creator A5053599868 @default.
• W2896959233 creator A5055082801 @default.
• W2896959233 creator A5055379110 @default.
• W2896959233 creator A5057570590 @default.
• W2896959233 creator A5059795103 @default.
• W2896959233 creator A5062163674 @default.
• W2896959233 creator A5063413978 @default.
• W2896959233 creator A5069326083 @default.
• W2896959233 creator A5071109160 @default.
• W2896959233 creator A5071860665 @default.
• W2896959233 creator A5074111657 @default.
• W2896959233 creator A5077071423 @default.
• W2896959233 creator A5080294551 @default.
• W2896959233 creator A5080401180 @default.
• W2896959233 creator A5081382916 @default.
• W2896959233 creator A5086342180 @default.
• W2896959233 creator A5087019197 @default.
• W2896959233 creator A5089045595 @default.
• W2896959233 creator A5091212827 @default.
• W2896959233 creator A5091714084 @default.
• W2896959233 date "2018-10-15" @default.
• W2896959233 modified "2023-10-18" @default.
• W2896959233 title "Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure" @default.
• W2896959233 cites W143952100 @default.
• W2896959233 cites W1591916013 @default.
• W2896959233 cites W1636391291 @default.
• W2896959233 cites W1666352640 @default.
• W2896959233 cites W1793540063 @default.
• W2896959233 cites W1874198492 @default.
• W2896959233 cites W1966240259 @default.
• W2896959233 cites W1969530159 @default.
• W2896959233 cites W1973929928 @default.
• W2896959233 cites W1981900811 @default.
• W2896959233 cites W1982254984 @default.
• W2896959233 cites W1982603620 @default.
• W2896959233 cites W1986838525 @default.
• W2896959233 cites W1989825818 @default.
• W2896959233 cites W1991664409 @default.
• W2896959233 cites W1992152055 @default.
• W2896959233 cites W1992542743 @default.
• W2896959233 cites W1994125767 @default.
• W2896959233 cites W2010867021 @default.
• W2896959233 cites W2011400811 @default.
• W2896959233 cites W2011663421 @default.
• W2896959233 cites W2017828716 @default.
• W2896959233 cites W2019766373 @default.
• W2896959233 cites W2022135873 @default.
• W2896959233 cites W2023945291 @default.
• W2896959233 cites W2024633528 @default.
• W2896959233 cites W2025819729 @default.
• W2896959233 cites W2029556699 @default.
• W2896959233 cites W2033968700 @default.
• W2896959233 cites W2038566124 @default.
• W2896959233 cites W2058426917 @default.
• W2896959233 cites W2060076676 @default.
• W2896959233 cites W2062854526 @default.
• W2896959233 cites W2063731747 @default.
• W2896959233 cites W2064385743 @default.
• W2896959233 cites W2074605175 @default.
• W2896959233 cites W2075809760 @default.
• W2896959233 cites W2077090955 @default.
• W2896959233 cites W2081107312 @default.
• W2896959233 cites W2085910914 @default.
• W2896959233 cites W2088564934 @default.
• W2896959233 cites W2089181978 @default.
• W2896959233 cites W2091651967 @default.
• W2896959233 cites W2094532272 @default.
• W2896959233 cites W2107746069 @default.
• W2896959233 cites W2119059014 @default.
• W2896959233 cites W2119103149 @default.
• W2896959233 cites W2120359573 @default.
• W2896959233 cites W2140654447 @default.
• W2896959233 cites W2141213208 @default.
• W2896959233 cites W2148856691 @default.
• W2896959233 cites W2151630650 @default.
• W2896959233 cites W2164590623 @default.
• W2896959233 cites W2230662505 @default.
• W2896959233 cites W2295213040 @default.
• W2896959233 cites W2324626880 @default.
• W2896959233 cites W2330494736 @default.
• W2896959233 cites W2406875629 @default.
• W2896959233 cites W2527885929 @default.

• next